Wilms' tumor in the adult--report of a case and review of the literature

Article Article scientifique Rapport de cas Wilms' tumor in the adult--report of a case and review of the literature eng 1999 author Tawil A author Cox J N author Roth Arnaud 134504 author Briner J author Droz J P author Remadi Sami 24612 105-111;discussion113-4 10.1016/S0344-0338(99)80081-8 10093830 0344-0338 Wilms' tumor is rare in adults. Its histology, grading and staging are identical to those in children. Investigators agree on a combined modality approach in the treatment of adult Wilms' tumor (AWT), but differ on how aggressive it should be. Some advocate adopting the current pediatric protocols which take into account tumor stage and grade. Others recommend using advanced disease regimens for all stages and grades. We report on an 18 year-old male with stage IV favorable histology Wilms' tumor. The patient underwent radical nephrectomy and received postoperative radiotherapy with intensive four-drug chemotherapy. He had one relapse after 12 months which was successfully treated with chemotherapy and radiotherapy. He remains in remission without relapses 36 months after the initial diagnosis. The genetics of Wilms' tumor has been well studied in children but is practically unknown in adults; karyotype and molecular genetic studies in this case were normal. Adolescent Antineoplastic Combined Chemotherapy Protocols/therapeutic use Combined Modality Therapy Genes, Wilms Tumor/genetics Humans Immunoenzyme Techniques Karyotyping Kidney Neoplasms/chemistry/genetics/pathology/therapy Lung Neoplasms/secondary/therapy Male Neoplasm Staging Nephrectomy Tomography, X-Ray Computed Tumor Markers, Biological/analysis Wilms Tumor/chemistry/genetics/secondary/therapy Dewey 616 Dewey 617 56 Département de médecine 221 57 Département de chirurgie 222 false 223 Groupe Roth Arnaud (oncologie) 285 Pathology, research and practice 195 2 46d5167b-8109-4a2f-8035-8ee2c8d25c21 Article (Published version) Restricted 1999_tawil_pathol_res_pract.pdf 4091140 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Wilms' tumor in the adult--report of a case and review of the literature	Pathology, research and practice			1999	580	0

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Remadi, Sami