Scientific article
Open access

DNA display of glycoconjugates to emulate oligomeric interactions of glycans

Published inBeilstein journal of organic chemistry, vol. 11, p. 707-719
Publication date2015

Glycans (carbohydrate portion of glycoproteins and glycolipids) frequently exert their function through oligomeric interactions involving multiple carbohydrate units. In efforts to recapitulate the diverse spatial arrangements of the carbohydrate units, assemblies based on hybridization of nucleic acid conjugates have been used to display simplified ligands with tailored interligand distances and valences. The programmability of the assemblies lends itself to a combinatorial display of multiple ligands. Recent efforts in the synthesis and applications of such conjugates are discussed.

  • Glycan
  • Glycoconjugate
  • DNA display
  • Multivalency
  • Nucleic acid conjugates
  • Oligomeric interaction
Citation (ISO format)
NOVOA, Alexandre, WINSSINGER, Nicolas. DNA display of glycoconjugates to emulate oligomeric interactions of glycans. In: Beilstein journal of organic chemistry, 2015, vol. 11, p. 707–719. doi: 10.3762/bjoc.11.81
Main files (1)
Article (Published version)
ISSN of the journal1860-5397

Technical informations

Creation06/08/2015 5:39:00 PM
First validation06/08/2015 5:39:00 PM
Update time03/14/2023 11:21:36 PM
Status update03/14/2023 11:21:36 PM
Last indexation10/18/2023 11:05:55 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack