Calcineurin inhibitor-free immunosuppressive regimen in type 1 diabetes patients receiving islet transplantation: single-group phase 1/2 trial

Maffi, Paola; Berney, Thierry; Nano, Rita; Niclauss, Nadja; Bosco, Domenico; Melzi, Raffaella; Mercalli, Alessia; Magistretti, Paola; De Cobelli, Francesco; Battaglia, Manuela; Scavini, Marina; Demuylder-Mischler, Sandrine; Secchi, Antonio; Piemonti, Lorenzo

doi:10.1097/TP.0000000000000396

Scientific article

English

Calcineurin inhibitor-free immunosuppressive regimen in type 1 diabetes patients receiving islet transplantation: single-group phase 1/2 trial

ContributorsMaffi, Paola; Berney, Thierry; Nano, Rita; Niclauss, Nadja; Bosco, Domenico; Melzi, Raffaella; Mercalli, Alessia; Magistretti, Paola; De Cobelli, Francesco; Battaglia, Manuela; Scavini, Marina; Demuylder-Mischler, Sandrine; Secchi, Antonio; Piemonti, Lorenzo

Published inTransplantation, vol. 98, no. 12, p. 1301-1309

Publication date2014

Abstract

Our final objective is to develop an adoptive therapy with tolerogenic donor-specific type 1 T regulatory cells for patients with type 1 diabetes undergoing islet transplantation. The achievement of this objective depends on the availability of an immunosuppressive treatment compatible with the survival, function, and expansion of type 1 T regulatory cells.

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

La transplantation d'îlots de Langerhans (623)

Citation (ISO format)

MAFFI, Paola et al. Calcineurin inhibitor-free immunosuppressive regimen in type 1 diabetes patients receiving islet transplantation: single-group phase 1/2 trial. In: Transplantation, 2014, vol. 98, n° 12, p. 1301–1309. doi: 10.1097/TP.0000000000000396

Article (Published version)

Identifiers

PID : unige:72686
DOI : 10.1097/TP.0000000000000396
PMID : 25286053

Journal ISSN0041-1337

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Calcineurin inhibitor-free immunosuppressive regimen in type 1 diabetes patients receiving islet transplantation: single-group phase 1/2 trial

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