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Title

Fatal myocardial aspergillosis in an immunosuppressed child

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Published in Journal of Pediatric Hematology / Oncology. 2001, vol. 23, no. 7, p. 456-9
Abstract A girl with resistant acute myeloid leukemia (AML) had a stem cell transplantation. Preceding transplantation, she had recurrent pneumonitis. No causative agent was identified. Despite several antibiotics including high-dose liposomal amphotericin-B, pulmonary infection progressed. Aspergillosis, always considered, could not be documented. She died from cardiac arrest on the second day after transplantation, with no forewarning of previous heart disease. Pericardial and myocardial aspergillosis was an autopsy finding. Pericardial and myocardial aspergillosis, rare manifestations of systemic aspergillosis, should be considered in any immunocompromised patient with long-lasting pulmonary infection, even in the absence of specific cardiac findings.
Keywords Amphotericin B/therapeutic useAntifungal Agents/therapeutic useAspergillosis/diagnosis/drug therapy/microbiologyAspergillus/isolation & purificationChildFatal OutcomeFemaleHematopoietic Stem Cell TransplantationHumansImmunocompromised HostLeukemia, Myeloid, Acute/complications/drug therapyLung Diseases, Fungal/drug therapy/microbiologyMyocarditis/diagnosis/drug therapy/microbiologyPericarditis/diagnosis/drug therapy/microbiology
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PMID: 11878582
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Structures
Research groups Etiologie des pneumonies et marqueurs inflammatoires chez l'enfant fébrile (183)
Radiologie neuro-diagnostique et neuro-interventionnelle en pédiatrie (842)
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OZSAHIN, Ayse Hulya et al. Fatal myocardial aspergillosis in an immunosuppressed child. In: Journal of Pediatric Hematology / Oncology, 2001, vol. 23, n° 7, p. 456-9. https://archive-ouverte.unige.ch/unige:72632

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Deposited on : 2015-05-18

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