Fatal myocardial aspergillosis in an immunosuppressed child

Article Article scientifique Rapport de cas Fatal myocardial aspergillosis in an immunosuppressed child eng 2001 author Ozsahin Ayse Hulya 121635 author Wacker Pierre 23992 author Brundler Marie-Anne 526487 author Starobinski Michel 31169 author Helg Claudine 132492 author Pastore Yves Dominique 28767 author Miralbell Raymond 116361 author Hanquinet Sylviane 133458 author Gervaix Alain 31715 author Chapuis Bernard 24001 author Humbert James Ronald 25322 456-459 10.1097/00043426-200110000-00013 11878582 1077-4114 A girl with resistant acute myeloid leukemia (AML) had a stem cell transplantation. Preceding transplantation, she had recurrent pneumonitis. No causative agent was identified. Despite several antibiotics including high-dose liposomal amphotericin-B, pulmonary infection progressed. Aspergillosis, always considered, could not be documented. She died from cardiac arrest on the second day after transplantation, with no forewarning of previous heart disease. Pericardial and myocardial aspergillosis was an autopsy finding. Pericardial and myocardial aspergillosis, rare manifestations of systemic aspergillosis, should be considered in any immunocompromised patient with long-lasting pulmonary infection, even in the absence of specific cardiac findings. Amphotericin B/therapeutic use Antifungal Agents/therapeutic use Aspergillosis/diagnosis/drug therapy/microbiology Aspergillus/isolation & purification Child Fatal Outcome Female Hematopoietic Stem Cell Transplantation Humans Immunocompromised Host Leukemia, Myeloid, Acute/complications/drug therapy Lung Diseases, Fungal/drug therapy/microbiology Myocarditis/diagnosis/drug therapy/microbiology Pericarditis/diagnosis/drug therapy/microbiology Dewey 616.0757 Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 62 Département de radiologie et informatique médicale 227 false 149 Etiologie des pneumonies et marqueurs inflammatoires chez l'enfant fébrile 183 504 Radiologie neuro-diagnostique et neuro-interventionnelle en pédiatrie 842 Journal of pediatric hematology/oncology 23 7 b4523be9-fb41-48ef-bb0f-9f668e50b923 Article (Published version) Restricted 456-459.pdf 353498 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Title	Published in	Year	Views	Downloads

Fatal myocardial aspergillosis in an immunosuppressed child	Journal of pediatric hematology/oncology	2001	591	0
Emergency splenectomy in the management of intracranial hemorrhage in childhood immune thrombocytopenic purpura	Journal of pediatric hematology/oncology	1999	543	0

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