UNIGE document Scientific Article
previous document  unige:7250  next document
add to browser collection

Fungemia in HIV-infected patients: a 12-year study in a tertiary care hospital

Kolarova, L.
Published in AIDS Patient Care STDS. 2001, vol. 15, no. 8, p. 407-410
Abstract Opportunistic infections caused by fungi are common in human immunodeficiency virus (HIV)-infected patients. We focused on severe infections as indicated by detectable fungemia. Medical charts available for patients having positive blood cultures with fungi at the University of Geneva Hospital were retrospectively (1989 to 2000) reviewed. Of 328 patients with fungemia during the study period, 315 (96%) medical charts were accessible. Of these 315 patients, 37 (12.2%) were HIV-positive, and 13 (35.1%) died within 6 months from their episode of fungemia. This was a lower mortality rate than for the HIV seronegative patients (45.8%). The median and average age of the 34 HIV-positive patients was 37.2 years, and 24 (64.9%) were males. Cryptococcus neoformans (n = 14) and Candida albicans (n = 12) were the most frequently identified species, followed by Candida glabrata (n = 3), of which 3 were mixed C. albicans + C. glabrata, Histoplasma capsulatum (n = 2), and Penicillium marneffei (n = 2). The frequency decreased significantly (p < 0.007) from the time period 1993 to 1996 (n = 21) to the period 1997 to 2000 (n = 6). Fungemias in HIV-infected patients have declined significantly since 1996. This coincides with the introduction of highly active antiretroviral therapy (HAART).
Keywords AIDS-Related Opportunistic Infections/blood/ epidemiologyAdolescentAdultAgedAged, 80 and overCandida/isolation & purificationCryptococcus/isolation & purificationFemaleFungemia/blood/ epidemiologyHistoplasma/isolation & purificationHumansLongitudinal StudiesMaleMedical RecordsMiddle AgedPenicillium/isolation & purificationRetrospective StudiesSwitzerland/epidemiology
PMID: 11522214
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
GARBINO, Jorge et al. Fungemia in HIV-infected patients: a 12-year study in a tertiary care hospital. In: AIDS Patient Care STDS, 2001, vol. 15, n° 8, p. 407-410. doi: 10.1089/108729101316914403 https://archive-ouverte.unige.ch/unige:7250

449 hits

0 download


Deposited on : 2010-06-21

Export document
Format :
Citation style :