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Title

Prognostic value of viremia in patients with long-standing human immunodeficiency virus infection. Swiss HIV Cohort Study Group

Authors
Perneger, T. V.
Published in Journal of Infectious Diseases. 1996, vol. 173, no. 6, p. 1388-1393
Abstract Human immunodeficiency virus (HIV) viremia was evaluated in 73 patients with long-standing infection to investigate its relationship with clinical or biologic parameters and to assess its use as a predictor of clinical progression and death. After adjustment for other parameters, baseline HIV RNA level was significantly associated with baseline clinical stage and CD4 cell count. During follow-up (mean, 14.6 months), 16 patients died; 34 others had clinical progression of disease. In multivariate analysis, mortality was better predicted by baseline CD4 cell count (relative hazard [RH] for 100-cell decrease, 3.5; 95% confidence interval [CI], 1.5-8.2; P =.003) than by HIV RNA (P =.28) or clinical stage. HIV RNA level was the best predictor of clinical progression (RH for 1 log increase, 2.8; 95% CI, 1.6-4.9; P <.001). Monitoring of HIV RNA level may help to identify patients who might benefit from antiretroviral or prophylactic therapy.
Keywords AdultCD4 Lymphocyte CountCohort StudiesDisease ProgressionDisease-Free SurvivalFemaleHIV/ physiologyHIV Infections/mortality/physiopathology/ virologyHumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRNA, Viral/ bloodViremia/mortality/ virology
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PMID: 8648210
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Other version: http://www.jstor.org/stable/pdfplus/30128148.pdf
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GALETTO-LACOUR, Annick et al. Prognostic value of viremia in patients with long-standing human immunodeficiency virus infection. Swiss HIV Cohort Study Group. In: Journal of Infectious Diseases, 1996, vol. 173, n° 6, p. 1388-1393. https://archive-ouverte.unige.ch/unige:7246

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Deposited on : 2010-06-21

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