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Scientific article
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Prognostic value of viremia in patients with long-standing human immunodeficiency virus infection. Swiss HIV Cohort Study Group

Published inThe Journal of infectious diseases, vol. 173, no. 6, p. 1388-1393
Publication date1996
Abstract

Human immunodeficiency virus (HIV) viremia was evaluated in 73 patients with long-standing infection to investigate its relationship with clinical or biologic parameters and to assess its use as a predictor of clinical progression and death. After adjustment for other parameters, baseline HIV RNA level was significantly associated with baseline clinical stage and CD4 cell count. During follow-up (mean, 14.6 months), 16 patients died; 34 others had clinical progression of disease. In multivariate analysis, mortality was better predicted by baseline CD4 cell count (relative hazard [RH] for 100-cell decrease, 3.5; 95% confidence interval [CI], 1.5-8.2; P =.003) than by HIV RNA (P =.28) or clinical stage. HIV RNA level was the best predictor of clinical progression (RH for 1 log increase, 2.8; 95% CI, 1.6-4.9; P <.001). Monitoring of HIV RNA level may help to identify patients who might benefit from antiretroviral or prophylactic therapy.

Keywords
  • Adult
  • CD4 Lymphocyte Count
  • Cohort Studies
  • Disease Progression
  • Disease-Free Survival
  • Female
  • HIV/ physiology
  • HIV Infections/mortality/physiopathology/ virology
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prognosis
  • Prospective Studies
  • RNA, Viral/ blood
  • Viremia/mortality/ virology
Citation (ISO format)
GALETTO-LACOUR, Annick et al. Prognostic value of viremia in patients with long-standing human immunodeficiency virus infection. Swiss HIV Cohort Study Group. In: The Journal of infectious diseases, 1996, vol. 173, n° 6, p. 1388–1393.
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ISSN of the journal0022-1899
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