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Physical and biological effects of a surface coating procedure on polyurethane catheters

Mathieu, H. J.
Published in Biomaterials. 1996, vol. 17, no. 7, p. 667-678
Abstract Central venous catheters are widely used in clinical practice; however, complications such as venous thrombosis or infection are frequent. The physical and biological effects of a coating procedure designed to improve the blood-contacting properties of polyurethane central venous catheters (CVCs) were studied. The surface atomic composition of poly(vinyl pyrrolidone) (PVP)-coated or uncoated Pellethane single lumen CVCs was characterized by electron spectroscopy for chemical analysis (ESCA), which confirmed the presence of an oxygen-rich PVP layer on the former material. Topological analysis of both single and triple lumen CVCs by scanning force microscopy (SFM) revealed a very smooth surface in PVP-coated catheters compared to the more frequent surface irregularities found either in uncoated Pellethane or in four additional randomly selected, commercially available triple lumen polyurethane CVCs. The PVP-coated Pellethane showed a strong reduction in either fibrinogen or fibronectin adsorption compared to all other PVP-free polyurethane CVCs. This decreased protein adsorption led to a proportional reduction in protein-mediated adhesion of either Staphylococcus aureus or Staphylococcus epidermidis and in the binding of a monoclonal antibody directed against the cell-binding domain of fibronectin. Increased surface smoothness and hydrophilic properties of polyurethane CVCs might decrease the risk of bacterial colonization and infection.
Keywords AdsorptionAntibodies, MonoclonalBacterial AdhesionCatheterization/ standardsCatheterization, Central Venous/ standardsElectron Probe MicroanalysisEnzyme-Linked Immunosorbent AssayFibronectins/immunology/metabolismHumansMicroscopy, Atomic ForcePolyurethanes/ chemistryPovidone/ chemistryStaphylococcal Infections/prevention & controlStaphylococcus aureus/metabolismStaphylococcus epidermidis/metabolismSurface Properties
PMID: 8672628
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FRANCOIS, Patrice et al. Physical and biological effects of a surface coating procedure on polyurethane catheters. In: Biomaterials, 1996, vol. 17, n° 7, p. 667-678. https://archive-ouverte.unige.ch/unige:7235

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Deposited on : 2010-06-21

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