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Title

Host-bacteria interactions in foreign body infections

Authors
Foster, T. J.
Published in Infection Control and Hospital Epidemiology. 1996, vol. 17, no. 8, p. 514-520
Abstract Persistent staphylococcal infections are a major medical problem, especially when they occur on implanted materials or intravascular catheters. This review describes some of the recently discovered molecular mechanisms of Staphylococcus aureus attachment to host proteins coating biomedical implants. These interactions involve specific surface proteins, called bacterial adhesins, that recognize specific domains of host proteins deposited on indwelling devices, such as fibronectin, fibrinogen, or fibrin. Elucidation of molecular mechanisms of S aureus adhesion to the different host proteins may lead to the development of specific inhibitors blocking attachment of S aureus, which may decrease the risk of bacterial colonization of indwelling devices.
Keywords Adhesins, BacterialAnimalsBacterial Adhesion/physiologyBacterial Outer Membrane ProteinsBacterial ProteinsCarrier ProteinsCatheters, Indwelling/ microbiologyCross InfectionFibrinogenHumansProstheses and Implants/ microbiologyProsthesis-Related InfectionsStaphylococcal InfectionsStaphylococcus aureus/ pathogenicity
Identifiers
PMID: 8875296
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Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.jstor.org/stable/30141285
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FRANCOIS, Patrice et al. Host-bacteria interactions in foreign body infections. In: Infection Control and Hospital Epidemiology, 1996, vol. 17, n° 8, p. 514-520. https://archive-ouverte.unige.ch/unige:7233

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Deposited on : 2010-06-21

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