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Biphasic decline of CD4 cell count during scheduled treatment interruptions

Fagard, Catherine
Bandelier, C. Y.
Ananworanich, Jintanat
Le Braz, Michelle
Gunthard, Huldrych
Garcia, Felipe
Published in AIDS. 2005, vol. 19, no. 4, p. 439-441
Abstract In 115 patients whose scheduled treatment interruptions (STI) lasted 24 weeks, the CD4 cell count declined by a median of 30 cells/ml/week during the first 4 weeks, compared with 3 cells/ml/week during the next 20 weeks. In multivariate regression, a pronounced early fall in CD4 cells correlated with a higher CD4 cell count at the start of STI, with more gain in CD4 cells during antiretroviral treatment preceding STI, and with a higher viral load at week 4.
Keywords Anti-HIV Agents/ administration & dosageAntiretroviral Therapy, Highly Active/methodsCD4 Lymphocyte CountDrug Administration ScheduleHIV Infections/drug therapy/ immunology/virologyHumansProspective StudiesViral Load
PMID: 15750398
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Research group Epidémiologie clinique (115)
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FAGARD, Catherine et al. Biphasic decline of CD4 cell count during scheduled treatment interruptions. In: AIDS, 2005, vol. 19, n° 4, p. 439-441. doi: 10.1097/01.aids.0000161774.29029.0e https://archive-ouverte.unige.ch/unige:7194

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Deposited on : 2010-06-21

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