UNIGE document Scientific Article
previous document  unige:7127  next document
add to browser collection

Comparison of sparfloxacin, temafloxacin, and ciprofloxacin for prophylaxis and treatment of experimental foreign-body infection by methicillin-resistant Staphylococcus aureus

Cagni, A.
Published in Antimicrobial agents and chemotherapy. 1995, vol. 39, no. 8, p. 1655-1660
Abstract The prophylactic and therapeutic activities of three broad-spectrum fluoroquinolones were evaluated in two different experimental models of foreign-body infections caused by methicillin-resistant Staphylococcus aureus (MRSA) susceptible to quinolones. In a guinea pig model of prophylaxis, subcutaneously implanted tissue cages were infected at a > 90% rate by 10(2) CFU of MRSA in control animals. A single dose of 50 mg of ciprofloxacin per kg of body weight administered intraperitoneally 3 h before bacterial challenge was less effective than an equivalent regimen of either sparfloxacin or temafloxacin in decreasing the rate of experimental infection in tissue cages challenged with increasing inocula of MRSA. In a rat model evaluating the therapy of chronic tissue cage infection caused by MRSA, the efficacy of a 7-day high-dose (50-mg/kg twice-daily) regimen of sparfloxacin, temafloxacin, or ciprofloxacin was compared to that of vancomycin (50 mg/kg twice daily). Active levels of sparfloxacin, temfloxacin, or ciprofloxacin were continuously present in tissue cage fluid during therapy, exceeding their MBCs for MRSA by 6- to 20-fold. Either temafloxacin, sparfloxacin, or vancomycin was significantly (P < 0.01) more active than ciprofloxacin in decreasing the viable counts of MRSA in tissue cage fluids. The different activities of ciprofloxacin compared with those of the other two quinolones against chronic tissue cage infections caused by MRSA did not involve the selective emergence of quinolone-resistant mutants. Temafloxacin and ciprofloxacin, which showed the most prominent differences in their in vivo activities, however, exhibited similar bactericidal properties and pharmacokinetic parameters in the rat model. In conclusion, both temafloxacin and sparfloxacin were significantly more active than ciprofloxacin for the prophylaxis or treatment of experimental foreign-body infections caused by a quinolone-susceptible strain of MRSA.
Keywords AnimalsAnti-Bacterial Agents/pharmacology/therapeutic useAnti-Infective Agents/pharmacokinetics/pharmacology/ therapeutic useCiprofloxacin/pharmacokinetics/pharmacology/therapeutic useFluoroquinolonesForeign Bodies/ complicationsGuinea PigsMethicillin ResistanceMicrobial Sensitivity TestsQuinolones/pharmacokinetics/pharmacology/therapeutic useRatsStaphylococcal Infections/ drug therapy/microbiology/prevention & controlStaphylococcus aureus/drug effectsVancomycin/pharmacology/therapeutic use
PMID: 7486895
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://aac.asm.org/cgi/reprint/39/8/1655.pdf
(ISO format)
CAGNI, A. et al. Comparison of sparfloxacin, temafloxacin, and ciprofloxacin for prophylaxis and treatment of experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. In: Antimicrobial agents and chemotherapy, 1995, vol. 39, n° 8, p. 1655-1660. doi: 10.1128/aac.39.8.1655 https://archive-ouverte.unige.ch/unige:7127

495 hits

0 download


Deposited on : 2010-06-21

Export document
Format :
Citation style :