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Regional differences in presentation of AIDS in Europe

Blaxhult, A.
Kirk, Ole
Pedersen, C.
Dietrich, M.
Barton, S. E.
Gatell, J. M.
Mulcahy, F.
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Published in Epidemiology and infection. 2000, vol. 125, no. 1, p. 143-151
Abstract Data were collected on 6578 patients diagnosed with AIDS at 52 clinical centres in 17 European countries during an 1-year period from 1979 to 1989. The centres were divided into four regions, North, Central, Southeast, and Southwest. Differences in the incidence of most AIDS-defining opportunistic infections and malignancies were found. After adjusting for known possible confounders, statistically significant differences between regions remained. Pneumocystis carinii pneumonia (PCP) was more common in Northern Europe, Kaposi's sarcoma and toxoplasmosis in Central Europe, cytomegalovirus retinitis in South-eastern Europe, and extrapulmonary tuberculosis in South-western Europe. These differences we attribute primarily to different degrees of exposure to the respective underlying pathogens. The prevalence of these and other micro-organisms will determine the clinical course of HIV infections in parts of Eastern Europe and elsewhere where the virus now is spreading.
Keywords AIDS-Related Opportunistic Infections/ epidemiologyAdultCytomegalovirus Retinitis/epidemiologyEurope/epidemiologyFemaleHumansIncidenceLongitudinal StudiesMalePneumonia, Pneumocystis/epidemiologyPrevalenceRegional Health PlanningSarcoma, Kaposi/epidemiologyToxoplasmosis/epidemiologyTuberculosis/epidemiology
PMID: 11057969
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BLAXHULT, A. et al. Regional differences in presentation of AIDS in Europe. In: Epidemiology and Infection, 2000, vol. 125, n° 1, p. 143-151. https://archive-ouverte.unige.ch/unige:7114

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Deposited on : 2010-06-21

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