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Scientific article
English

Trends in the treatment of orthopaedic prosthetic infections

Contributors

Bernard, Louis; Hoffmeyer, Pierre; Assal, Mathieu; Vaudaux, Pierre; Schrenzel, Jacques; Lew, Daniel Pablo

Published in

The journal of antimicrobial chemotherapy, vol. 53, no. 2, p. 127-129

Publication date

2004

Abstract

The most commonly used therapy for prosthetic joint infection is a two-stage prosthetic exchange separated by 6 weeks of intravenous antibiotic therapy. This often results in long periods of hospitalization, morbidity, severe functional impairment and sometimes increased mortality. Therefore novel and challenging therapeutic approaches have been attempted, particularly in hip prosthetic infection. This includes, whenever possible, according to the type of microorganism, antibacterial susceptibility and clinical presentation (including age and comorbidities): (i) less aggressive surgical techniques (debridement and prosthesis retention, or re-implantation with a single-stage exchange arthroplasty); and (ii) antibiotic combinations active against biofilm-associated bacteria, including rifampicin (particularly with quinolones) with excellent bio-availability which allow prolonged and efficient oral therapy.

Keywords

  • Anti-Bacterial Agents/ therapeutic use
  • Arthroplasty, Replacement
  • Clinical Trials as Topic
  • Humans
  • Prosthesis-Related Infections/drug therapy/microbiology/surgery/ therapy
  • Reoperation

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

BERNARD, Louis et al. Trends in the treatment of orthopaedic prosthetic infections. In: The journal of antimicrobial chemotherapy, 2004, vol. 53, n° 2, p. 127–129. doi: 10.1093/jac/dkh033

Main files (1)

Article

Identifiers

Additional URL for this publication

http://jac.oxfordjournals.org/cgi/reprint/53/2/127.pdf

Journal ISSN

0305-7453
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Technical informations

Creation

21/06/2010 10:23:14

First validation

21/06/2010 10:23:14

Update

14/03/2023 15:42:45

Status update

14/03/2023 15:42:45

Last indexation

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