Scientific article

Trends in the treatment of orthopaedic prosthetic infections

Published inThe journal of antimicrobial chemotherapy, vol. 53, no. 2, p. 127-129
Publication date2004

The most commonly used therapy for prosthetic joint infection is a two-stage prosthetic exchange separated by 6 weeks of intravenous antibiotic therapy. This often results in long periods of hospitalization, morbidity, severe functional impairment and sometimes increased mortality. Therefore novel and challenging therapeutic approaches have been attempted, particularly in hip prosthetic infection. This includes, whenever possible, according to the type of microorganism, antibacterial susceptibility and clinical presentation (including age and comorbidities): (i) less aggressive surgical techniques (debridement and prosthesis retention, or re-implantation with a single-stage exchange arthroplasty); and (ii) antibiotic combinations active against biofilm-associated bacteria, including rifampicin (particularly with quinolones) with excellent bio-availability which allow prolonged and efficient oral therapy.

  • Anti-Bacterial Agents/ therapeutic use
  • Arthroplasty, Replacement
  • Clinical Trials as Topic
  • Humans
  • Prosthesis-Related Infections/drug therapy/microbiology/surgery/ therapy
  • Reoperation
Citation (ISO format)
BERNARD, Louis et al. Trends in the treatment of orthopaedic prosthetic infections. In: The journal of antimicrobial chemotherapy, 2004, vol. 53, n° 2, p. 127–129. doi: 10.1093/jac/dkh033
Updates (1)
ISSN of the journal0305-7453

Technical informations

Creation06/21/2010 10:23:14 AM
First validation06/21/2010 10:23:14 AM
Update time03/14/2023 3:42:45 PM
Status update03/14/2023 3:42:45 PM
Last indexation08/28/2023 6:10:58 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack