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Trends in the treatment of orthopaedic prosthetic infections

Published in The journal of antimicrobial chemotherapy. 2004, vol. 53, no. 2, p. 127-129
Abstract The most commonly used therapy for prosthetic joint infection is a two-stage prosthetic exchange separated by 6 weeks of intravenous antibiotic therapy. This often results in long periods of hospitalization, morbidity, severe functional impairment and sometimes increased mortality. Therefore novel and challenging therapeutic approaches have been attempted, particularly in hip prosthetic infection. This includes, whenever possible, according to the type of microorganism, antibacterial susceptibility and clinical presentation (including age and comorbidities): (i) less aggressive surgical techniques (debridement and prosthesis retention, or re-implantation with a single-stage exchange arthroplasty); and (ii) antibiotic combinations active against biofilm-associated bacteria, including rifampicin (particularly with quinolones) with excellent bio-availability which allow prolonged and efficient oral therapy.
Keywords Anti-Bacterial Agents/ therapeutic useArthroplasty, ReplacementClinical Trials as TopicHumansProsthesis-Related Infections/drug therapy/microbiology/surgery/ therapyReoperation
PMID: 14688050
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Other version: http://jac.oxfordjournals.org/cgi/reprint/53/2/127.pdf
Research group Chirurgie orthopédique et traumatologique (98)
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BERNARD, Louis et al. Trends in the treatment of orthopaedic prosthetic infections. In: The journal of antimicrobial chemotherapy, 2004, vol. 53, n° 2, p. 127-129. doi: 10.1093/jac/dkh033 https://archive-ouverte.unige.ch/unige:7098

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Deposited on : 2010-06-21

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