

Other version: http://www.intmedpress.com/journals/avt/abstract.cfm?id=534&pid=88
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Absence of resistance mutations in antiretroviral-naive patients treated with ritonavir-boosted saquinavir |
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Published in | Antiviral Therapy. 2006, vol. 11, no. 5, p. 631-635 | |
Abstract | BACKGROUND: There are few data on the selection of resistance by ritonavir-boosted saquinavir (SQV/r), particularly in antiretroviral (ARV)-naive patients. OBJECTIVE: To assess the incidence of virological failure and evolution of resistance in ARV-naive individuals receiving SQV/r in the induction phase of the Staccato trial. METHODS: ARV-naive subjects (n = 272) received SQV/r 1,600/100 mg once daily with two nucleoside reverse transcriptase inhibitors (NRTIs) for at least 24 weeks. Patients were defined as having virological failure (VF) when there were two consecutive HIV-1 RNA measurements > 500 copies/ml after week 12. Viral genotypes (reverse transcriptase [RT] and protease [PRO]) were determined at baseline in all patients and as close as possible to the time of initial failure in patients experiencing VF. RESULTS: VF was observed in 9/272 patients receiving SQV/r 1,600/100 mg once daily with two NRTIs (3.3%) and occurred 19-48 weeks after treatment initiation. Eight of these patients were evaluable at failure. No major PRO mutations were detected, but 2/8 displayed single new minor PRO substitutions (M36I, L10I) at VF that were known or suspected not to have been present at baseline; both these substitutions exist as natural polymorphisms. A third patient displayed a single new RT mutation (M184I). CONCLUSIONS: SQV/r plus two NRTIs (1,600/100 mg once daily) is an effective initial treatment option for ARV-naive patients, resulting in a low rate of viral rebound (3.3%). Furthermore, no major protease mutations were detected following VF, suggesting that future treatment options are preserved. | |
Keywords | Adult — Antiretroviral Therapy, Highly Active — Drug Resistance, Viral/ genetics — Female — Genotype — HIV Infections/ drug therapy/enzymology/virology — HIV Protease/ genetics/metabolism — HIV Protease Inhibitors/ therapeutic use — HIV Reverse Transcriptase/antagonists & inhibitors/ genetics/metabolism — HIV-1/enzymology/ genetics — Humans — Male — Mutation — Reverse Transcriptase Inhibitors/therapeutic use — Ritonavir/ therapeutic use — Saquinavir/ therapeutic use — Thailand — Treatment Failure — Viral Load | |
Identifiers | PMID: 16964832 | |
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![]() ![]() Other version: http://www.intmedpress.com/journals/avt/abstract.cfm?id=534&pid=88 |
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Citation (ISO format) | ANANWORANICH, Jintanat et al. Absence of resistance mutations in antiretroviral-naive patients treated with ritonavir-boosted saquinavir. In: Antiviral Therapy, 2006, vol. 11, n° 5, p. 631-635. https://archive-ouverte.unige.ch/unige:7081 |