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Scientific article
English

Subcritical fluid extraction of opiates in hair of drug addicts

Contributors

Edder, Patrick; Staub, Christian; Veuthey, Jean-Luc; Pierroz, I.; Haerdi, Werner

Published in

Journal of chromatography. B, vol. 658, no. 1, p. 75-86

Publication date

1994

Abstract

Hair analysis is a useful complement to blood and urine analysis in forensic science, but current procedures are tedious and time consuming. Owing to the difficulty of having a sufficient amount of hair in order to perform the optimization of the extraction method, standard hair was made and the procedure is described. The spiking method is reproducible and linearity can be obtained. Subcritical fluid extraction of opiates from standard and drug addicts' hair was optimized (extraction phase composition, extraction time, etc.) and compared with other extraction techniques (basic and acid hydrolysis, organic solvent and enzymatic digestion) followed by solid-phase extraction. Recovery, coefficient of variation, linearity, detection limits and quantification limits for the subcritical fluid extraction of opiates in hair are described.

Keywords

  • Codeine/analysis
  • Ethylamines/analysis
  • Ethylmorphine/analysis
  • Gas Chromatography-Mass Spectrometry
  • Hair/chemistry/ultrastructure
  • Humans
  • Microscopy, Electron, Scanning
  • Morphine/analysis
  • Morphine Derivatives/analysis
  • Narcotics/isolation & purification
  • Substance Abuse Detection/instrumentation
  • Substance-Related Disorders/metabolism
  • Water

UNIGE affiliation entities

Citation (ISO format)

EDDER, Patrick et al. Subcritical fluid extraction of opiates in hair of drug addicts. In: Journal of chromatography. B, 1994, vol. 658, n° 1, p. 75–86. doi: 10.1016/0378-4347(94)00220-7

Identifiers

Journal ISSN

1570-0232
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Technical informations

Creation

15/06/2010 13:59:00

First validation

15/06/2010 13:59:00

Update

13/03/2026 08:29:57

Status update

13/03/2026 08:29:57

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13/03/2026 08:33:56
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