Cocaine distribution in wild Erythroxylum species

Bieri, Stefan; Brachet, Anne; Veuthey, Jean-Luc; Christen, Philippe

doi:10.1016/j.jep.2005.08.021

Scientific article

English

Cocaine distribution in wild Erythroxylum species

Contributors

Bieri, Stefan; Brachet, Anne; Veuthey, Jean-Luc; Christen, Philippe

Published in

Journal of ethnopharmacology, vol. 103, no. 3, p. 439-447

Publication date

2006

Abstract

Cocaine distribution was studied in leaves of wild Erythroxylum species originating from Bolivia, Brazil, Ecuador, Paraguay, Peru, Mexico, USA, Venezuela and Mauritius. Among 51 species, 28 had never been phytochemically investigated before. Cocaine was efficiently and rapidly extracted with methanol, using focused microwaves at atmospheric pressure, and analysed without any further purification by capillary gas chromatography coupled to mass spectrometry. Cocaine was reported for the first time in 14 species. Erythroxylum laetevirens was the wild species with the highest cocaine content. Its qualitative chromatographic profile also revealed other characteristic tropane alkaloids. Finally, its cocaine content was compared to those of two cultivated coca plants as well as with a coca tea bag sample.

Keywords

Coca/chemistry
Cocaine/analysis
Dopamine Uptake Inhibitors/analysis
Erythroxylaceae/chemistry/classification
Gas Chromatography-Mass Spectrometry
Mauritius
Microwaves
North America
Plant Leaves
South America
Tropanes/analysis

UNIGE affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

BIERI, Stefan et al. Cocaine distribution in wild Erythroxylum species. In: Journal of ethnopharmacology, 2006, vol. 103, n° 3, p. 439–447. doi: 10.1016/j.jep.2005.08.021

Article (Published version)

Identifiers

PID : unige:6711
DOI : 10.1016/j.jep.2005.08.021
PMID : 16199132

Journal ISSN

0378-8741

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Cocaine distribution in wild Erythroxylum species

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Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

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Creation

First validation

Update

Status update

Last indexation