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Scientific article
English

Micellar and microemulsion electrokinetic chromatography of selected anesthetic drugs

Contributors

Cherkaoui, Samir; Veuthey, Jean-Luc

Published in

Journal of separation science, vol. 25, no. 15-17, p. 1073-1078

Publication date

2002

Abstract

A microemulsion electrokinetic chromatography method is described for the simultaneous analysis of local anesthetic drugs, including lidocaine, mepivacaine, bupivacaïne, cinchocaine, cocaine, prilocaine, and ketamine. The effect of the microemulsion composition such as SDS concentration, octane and 1-butanol percentages, as well as the separation temperature, on the electrophoretic behavior of the investigated drugs is described. Results show that the migration window is mainly affected by the SDS concentration in the microemulsion buffer. Adequate separation was performed with an uncoated fused silica capillary (48.5 cm total length x 50 μm ID) and a microemulsion buffer consisting of 50 mM octane, 80 mM sodium dodecyl sulfate, 800 mM 1-butanol, and 10 mM borate buffer (pH 9.0). Retention factors of the investigated anesthetic drugs were highly correlated with the octanol-water partition coefficients. Finally, separation characteristics in MEEKC were compared to those obtained in MEKC under similar micellar conditions. Results indicate the superiority of microemulsion pseudo-phases in terms of selectivity and separation window control.

Keywords

  • Micellar electrokinetic chromatography
  • Microemulsion electrokinetic chromatography
  • Anesthetic drugs

UNIGE affiliation entities

Citation (ISO format)

CHERKAOUI, Samir, VEUTHEY, Jean-Luc. Micellar and microemulsion electrokinetic chromatography of selected anesthetic drugs. In: Journal of separation science, 2002, vol. 25, n° 15-17, p. 1073–1078.

Main files (1)

Article (Published version)

Identifiers

  • PID : unige:6443

Journal ISSN

1615-9306
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Technical informations

Creation

03/05/2010 08:47:00

First validation

03/05/2010 08:47:00

Update

14/03/2023 15:28:33

Status update

14/03/2023 15:28:33

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