Scientific article
Open access

The 20 years of PROSITE

Published inNucleic acids research, vol. 36, no. Database issue, p. D245-249
Publication date2008

PROSITE consists of documentation entries describing protein domains, families and functional sites, as well as associated patterns and profiles to identify them. It is complemented by ProRule, a collection of rules based on profiles and patterns, which increases the discriminatory power of profiles and patterns by providing additional information about functionally and/or structurally critical amino acids. In this article, we describe the implementation of a new method to assign a status to pattern matches, the new PROSITE web page and a new approach to improve the specificity and sensitivity of PROSITE methods. The latest version of PROSITE (release 20.19 of 11 September 2007) contains 1319 patterns, 745 profiles and 764 ProRules. Over the past 2 years, about 200 domains have been added, and now 53% of UniProtKB/Swiss-Prot entries (release 54.2 of 11 September 2007) have a PROSITE match. PROSITE is available on the web at: http://www.expasy.org/prosite/.

  • Bacterial Proteins
  • Databases, Protein
  • History, 20th Century
  • History, 21st Century
  • Internet
  • Protein Structure, Tertiary
  • Proteins
  • Sequence Alignment
  • Sequence Analysis, Protein
  • Software
  • User-Computer Interface
Research group
Citation (ISO format)
HULO, Nicolas et al. The 20 years of PROSITE. In: Nucleic acids research, 2008, vol. 36, n° Database issue, p. D245–249. doi: 10.1093/nar/gkm977
Main files (1)
Article (Accepted version)
ISSN of the journal0305-1048

Technical informations

Creation12/11/2008 11:05:00 AM
First validation12/11/2008 11:05:00 AM
Update time03/14/2023 2:59:31 PM
Status update03/14/2023 2:59:31 PM
Last indexation05/02/2024 11:02:17 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack