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The 20 years of PROSITE

Cuche, Béatrice A.
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Published in Nucleic acids research. 2008, vol. 36, no. Database issue, p. D245-9
Abstract PROSITE consists of documentation entries describing protein domains, families and functional sites, as well as associated patterns and profiles to identify them. It is complemented by ProRule, a collection of rules based on profiles and patterns, which increases the discriminatory power of profiles and patterns by providing additional information about functionally and/or structurally critical amino acids. In this article, we describe the implementation of a new method to assign a status to pattern matches, the new PROSITE web page and a new approach to improve the specificity and sensitivity of PROSITE methods. The latest version of PROSITE (release 20.19 of 11 September 2007) contains 1319 patterns, 745 profiles and 764 ProRules. Over the past 2 years, about 200 domains have been added, and now 53% of UniProtKB/Swiss-Prot entries (release 54.2 of 11 September 2007) have a PROSITE match. PROSITE is available on the web at: http://www.expasy.org/prosite/.
Keywords Bacterial ProteinsDatabases, ProteinHistory, 20th CenturyHistory, 21st CenturyInternetProtein Structure, TertiaryProteinsSequence AlignmentSequence Analysis, ProteinSoftwareUser-Computer Interface
PMID: 18003654
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Research group Calipho (80)
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HULO, Nicolas et al. The 20 years of PROSITE. In: Nucleic acids research, 2008, vol. 36, n° Database issue, p. D245-9. doi: 10.1093/nar/gkm977 https://archive-ouverte.unige.ch/unige:641

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Deposited on : 2008-12-11

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