Scientific article
Open access

OrthoDB: the hierarchical catalog of eukaryotic orthologs

Published inNucleic acids research, vol. 36, no. Database issue, p. D271-275
Publication date2008

The concept of orthology is widely used to relate genes across different species using comparative genomics, and it provides the basis for inferring gene function. Here we present the web accessible OrthoDB database that catalogs groups of orthologous genes in a hierarchical manner, at each radiation of the species phylogeny, from more general groups to more fine-grained delineations between closely related species. We used a COG-like and Inparanoid-like ortholog delineation procedure on the basis of all-against-all Smith-Waterman sequence comparisons to analyze 58 eukaryotic genomes, focusing on vertebrates, insects and fungi to facilitate further comparative studies. The database is freely available at http://cegg.unige.ch/orthodb.

  • Databases
  • Genetic
  • Fungi
  • Genomics
  • Insects
  • Internet
  • Phylogeny
  • Proteomics
  • User-Computer Interface
  • Vertebrates
Citation (ISO format)
KRIVENTSEVA, Evgenia et al. OrthoDB: the hierarchical catalog of eukaryotic orthologs. In: Nucleic acids research, 2008, vol. 36, n° Database issue, p. D271–275. doi: 10.1093/nar/gkm845
Main files (1)
Article (Accepted version)
ISSN of the journal0305-1048

Technical informations

Creation12/09/2008 11:48:00 AM
First validation12/09/2008 11:48:00 AM
Update time03/14/2023 2:59:30 PM
Status update03/14/2023 2:59:30 PM
Last indexation10/18/2023 10:07:37 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack