UNIGE document Doctoral Thesis
previous document  unige:6000  next document
add to browser collection

Characterization of a Novel Tetraspanin-Rich, HIV-1-Containing Compartment in Dendritic Cells

Defense Thèse de doctorat : Univ. Genève, 2008 - Sc. 4000 - 2008/06/26
Abstract Dendritic cells (DC) are crucial components of the early events of HIV infection. DC capture and internalize HIV-1 at mucosal surfaces and efficiently transfer, in the absence of viral replication in DC, the virus to CD4+ T cells through infectious synapses (trans-infection pathway). Alternatively, HIV-1 replicates in DC, the resulting DC-T cell viral transfer resulting exclusively from de novo produced viral particles in infected DC (cis-infection pathway). Our results clearly indicate that, for both pathways, HIV-1 is internalized into a novel, non-lysosomial, tetraspanin-rich compartment in DC. Subsequently, the differential recruitment, during the cis-infection pathway, of the AP-3 complex (adaptor protein complex 3), a complex involved in the viral protein Gag targeting to the membranes of late endosomes/MVBs, argues in favour of a potential role of the tetraspanin-rich compartment in HIV-1 production in DC.
Keywords HIV-1Dendritic cellsInfectious synapsesCell-to-cell transmissionVirologyInfectious disease
URN: urn:nbn:ch:unige-60000
Full text
Thesis (7 MB) - public document Free access
(ISO format)
GARCIA, Eduardo. Characterization of a Novel Tetraspanin-Rich, HIV-1-Containing Compartment in Dendritic Cells. Université de Genève. Thèse, 2008. doi: 10.13097/archive-ouverte/unige:6000 https://archive-ouverte.unige.ch/unige:6000

399 hits



Deposited on : 2010-04-19

Export document
Format :
Citation style :