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Scientific article
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English

Impaired antibody response causes persistence of prototypic T cell-contained virus

Contributors

Bergthaler, Andréas; Flatz, Lukas; Verschoor, Admar; Hegazy, Ahmed N.; Holdener, Martin; Fink, Katja; Eschli, Bruno; Merkler, Doron; Sommerstein, Rami; Horvath, Edit; Fernandez, Marylise; Fitsche, André; Senn, Beatrice M.; Verbeek, J Sjef; Odermatt, Bernhard; Siegrist, Claire-Anne; Pinschewer, Daniel

Published in

PLoS biology, vol. 7, no. 4, e1000080

Publication date

2009

Abstract

CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to control of lymphocytic choriomeningitis virus (LCMV), a prototypic mouse model of systemic persistent infection. Mice expressing transgenic B cell receptors of LCMV-unrelated specificity, and mice unable to produce soluble immunoglobulin M (IgM) exhibited protracted viremia or failed to resolve LCMV. Virus control depended on immunoglobulin class switch, but neither on complement cascades nor on Fc receptor gamma chain or Fc gamma receptor IIB. Cessation of viremia concurred with the emergence of viral envelope-specific antibodies, rather than with neutralizing serum activity, and even early nonneutralizing IgM impeded viral persistence. This important role for virus-specific antibodies may be similarly underappreciated in other primarily T cell-controlled infections such as HIV and hepatitis C virus, and we suggest this contribution of antibodies be given consideration in future strategies for vaccination and immunotherapy.

Keywords

  • Animals
  • Antibodies, Viral/physiology
  • Arenaviridae Infections/immunology
  • CD8-Positive T-Lymphocytes/physiology
  • Complement System Proteins/immunology
  • Disease Models, Animal
  • Immunoglobulin Class Switching/physiology
  • Immunoglobulin G/immunology
  • Immunoglobulin M/immunology
  • Lymphocytic choriomeningitis virus/immunology
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Receptors, Antigen, B-Cell
  • Viral Load
  • Viremia/immunology
  • Virus Diseases/immunology

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

BERGTHALER, Andréas et al. Impaired antibody response causes persistence of prototypic T cell-contained virus. In: PLoS biology, 2009, vol. 7, n° 4, p. e1000080. doi: 10.1371/journal.pbio.1000080

Main files (1)

Article (Published version)

Identifiers

Additional URL for this publication

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672599/?tool=pubmed

Journal ISSN

1544-9173
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807downloads

Technical informations

Creation

30/03/2010 11:49:00

First validation

30/03/2010 11:49:00

Update

14/10/2025 07:02:21

Status update

14/03/2023 15:26:02

Last indexation

02/11/2026 16:25:11
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