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Copper-Catalyzed Asymmetric Conjugate Addition to α-Alkylidene Cycloalkanones

Woodward, Simon
Published in Synlett. 2015, vol. 26, no. 07, p. 901-906
Abstract The asymmetric copper-catalyzed conjugate addition to α-alkylidene cycloalkanones, substituted at their terminal position with aromatic and aliphatic groups, is reported. While high enantioselectivity is reached using chiral phosphoramidite ligands, with R3Al reagents, moderate diastereoselectivity was observed upon hydrolysis of the aluminium enolates. A Grignard reagent also react with high diastereo­selectivity.
Keywords α-alkylidene cycloalkanonesConjugate additionCopperTrialkylaluminium reagentsGrignard reagents
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GARCIA, Pierre et al. Copper-Catalyzed Asymmetric Conjugate Addition to α-Alkylidene Cycloalkanones. In: Synlett, 2015, vol. 26, n° 07, p. 901-906. doi: 10.1055/s-0034-1380165 https://archive-ouverte.unige.ch/unige:55652

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Deposited on : 2015-04-21

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