Copper-Catalyzed Asymmetric Conjugate Addition to α-Alkylidene Cycloalkanones

Article Article scientifique Article Copper-Catalyzed Asymmetric Conjugate Addition to α-Alkylidene Cycloalkanones eng 2015 author Garcia Pierre 812352 author Germain Nicolas 733490 author Woodward Simon author Alexakis Alexandre 123950 901-906 10.1055/s-0034-1380165 0936-5214 The asymmetric copper-catalyzed conjugate addition to α-alkylidene cycloalkanones, substituted at their terminal position with aromatic and aliphatic groups, is reported. While high enantioselectivity is reached using chiral phosphoramidite ligands, with R3Al reagents, moderate diastereoselectivity was observed upon hydrolysis of the aluminium enolates. A Grignard reagent also react with high diastereoselectivity. α-alkylidene cycloalkanones Conjugate addition Copper Trialkylaluminium reagents Grignard reagents Dewey 540 36 Département de chimie organique 141 false Synlett 26 07 3a544f31-9659-4c31-afc1-542b73ee36b2 Article (Published version) Restricted s-0034-1380165.pdf 208041 application/pdf restrictedAccess Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

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Copper-Catalyzed Asymmetric Conjugate Addition to α-Alkylidene Cycloalkanones	Synlett			2015	803	0

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Garcia, Pierre