Cognitive Decline Preceding the Onset of Psychosis in Patients With 22q11.2 Deletion Syndrome

Vorstman, Jacob A S; Breetvelt, Elemi J; Duijff, Sasja N; Eliez, Stéphan; Schneider, Maude; Jalbrzikowski, Maria; Armando, Marco; Vicari, Stefano; Shashi, Vandana; Hooper, Stephen R; Chow, Eva W C; Fung, Wai Lun Alan; Butcher, Nancy J; Young, Donald A; McDonald-McGinn, Donna M; Vogels, Annick; van Amelsvoort, Therese; Gothelf, Doron; Weinberger, Ronnie; Weizman, Abraham; Klaassen, Petra W J; Koops, Sanne; Kates, Wendy R; Antshel, Kevin M; Simon, Tony J; Ousley, Opal Y; Swillen, Ann; Gur, Raquel E; Bearden, Carrie E; Kahn, René S; Bassett, Anne S

doi:10.1001/jamapsychiatry.2014.2671

Scientific article

English

Cognitive Decline Preceding the Onset of Psychosis in Patients With 22q11.2 Deletion Syndrome

Published inJAMA psychiatry, vol. 72, no. 4, p. 377-385

Publication date2015

Abstract

Patients with 22q11.2 deletion syndrome (22q11DS) have an elevated (25%) risk of developing schizophrenia. Recent reports have suggested that a subgroup of children with 22q11DS display a substantial decline in cognitive abilities starting at a young age.

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

Research groups

Laboratoire d'imagerie et de psychopathologie développementale (693)

Citation (ISO format)

VORSTMAN, Jacob A S et al. Cognitive Decline Preceding the Onset of Psychosis in Patients With 22q11.2 Deletion Syndrome. In: JAMA psychiatry, 2015, vol. 72, n° 4, p. 377–385. doi: 10.1001/jamapsychiatry.2014.2671

Article (Published version)

Identifiers

PID : unige:55310
DOI : 10.1001/jamapsychiatry.2014.2671
PMID : 25715178

Journal ISSN2168-622X

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Creation10/03/2015 16:43:00

First validation10/03/2015 16:43:00

Update13/10/2025 21:33:39

Status update14/03/2023 23:09:15

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Cognitive Decline Preceding the Onset of Psychosis in Patients With 22q11.2 Deletion Syndrome

Patients with 22q11.2 deletion syndrome (22q11DS) have an elevated (25%) risk of developing schizophrenia. Recent reports have suggested that a subgroup of children with 22q11DS display a substantial decline in cognitive abilities starting at a young age.

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