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Neuropathological changes in aging brain

Papadimitropoulou, Adriana
Published in Advances in experimental medicine and biology. 2015, vol. 821, p. 11-7
Abstract Neuropathological hallmarks of Alzheimer's disease (AD) include tangles (NFT) and beta amyloid (Aβ) plaques. Despite numerous neuropathological studies that assessed the relationship of cognitive decline with neuropathologic lesions, their correlation still remains unclear. NFTs and Aβ plaques have been widely implicated and described in normal aging. The number of NFTs in the CA1 and the entorhinal cortex seems to be more closely related to cognitive status, compared to the amyloid load whose role still remains controversial in the AD. In this review, we refer to our main studies performed in Geneva during the past two decades attempting to assess the correlation of pathology with clinical expression. The theory of cognitive reserve has been proposed for further understanding of interindividual differences in terms of compensation despite the presence of pathological lesions. The increasing prevalence of the AD, the limitations of actual treatments, as well as the high public cost reflect the imperative need for better therapeutic and early diagnosis strategies in the future.
Keywords Age FactorsAgedAging/metabolism/pathologyAlzheimer Disease/metabolism/pathologyAmyloid beta-Peptides/chemistry/metabolismBrain/metabolism/pathologyBrain ChemistryHumansNeurofibrillary Tangles/chemistry/metabolism/pathologyPlaque, Amyloid/metabolism/pathologySeverity of Illness Index
PMID: 25416106
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Research groups Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577)
Groupe Giannakopoulos Panteleimon (psychiatrie générale) (201)
(ISO format)
XEKARDAKI, Aikaterini et al. Neuropathological changes in aging brain. In: Advances in experimental medicine and biology, 2015, vol. 821, p. 11-7. doi: 10.1007/978-3-319-08939-3_6 https://archive-ouverte.unige.ch/unige:55269

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Deposited on : 2015-04-08

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