Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age

Ha Vinh Leuchter, Elisa Russia Tuyet Mai; Gui Levy, Laura; Poncet, Antoine; Hagmann, Cornelia; Lodygensky, Gregory Anton; Martin, Ernst; Koller, Brigitte Marie; Darque, Alexandra; Bucher, Hans Ulrich; Hüppi, Petra Susan

doi:10.1001/jama.2014.9645

Scientific article

English

Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age

ContributorsHa Vinh Leuchter, Elisa Russia Tuyet Mai; Gui Levy, Laura; Poncet, Antoine; Hagmann, Cornelia; Lodygensky, Gregory Anton; Martin, Ernst; Koller, Brigitte Marie; Darque, Alexandra; Bucher, Hans Ulrich; Hüppi, Petra Susan

Published inJAMA, vol. 312, no. 8, p. 817-824

Publication date2014

Abstract

Premature infants are at risk of developing encephalopathy of prematurity, which is associated with long-term neurodevelopmental delay. Erythropoietin was shown to be neuroprotective in experimental and retrospective clinical studies.

Keywords

Brain/pathology
Brain Diseases/prevention & control
Double-Blind Method
Erythropoietin/administration & dosage
Humans
Infant
Infant, Newborn
Infant, Premature
Magnetic Resonance Imaging
Neuroprotective Agents/administration & dosage
Recombinant Proteins/administration & dosage
Retinopathy of Prematurity/prevention & control

Affiliation

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research group

Citation (ISO format)

HA VINH LEUCHTER, Elisa Russia Tuyet Mai et al. Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age. In: JAMA, 2014, vol. 312, n° 8, p. 817–824. doi: 10.1001/jama.2014.9645

Article (Published version)

Identifiers

PID : unige:55131
DOI : 10.1001/jama.2014.9645
PMID : 25157725

ISSN of the journal0098-7484

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Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age

Premature infants are at risk of developing encephalopathy of prematurity, which is associated with long-term neurodevelopmental delay. Erythropoietin was shown to be neuroprotective in experimental and retrospective clinical studies.

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