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Modulating physicochemical properties of drugs to optimise topical delivery: novel prodrugs of aciclovir to improve its cutaneous and ocular bioavailability using iontophoresis or supersaturated formulations

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Defense Thèse de doctorat : Univ. Genève, 2015 - Sc. 4774 - 2015/03/18
Abstract In this project it was decided to investigate how different prodrugs could be used to improve the topical delivery of aciclovir (ACV) through passive and active, electrically-assisted delivery into and across different biological barriers. Chapter 1 describeds an investigation of the topical iontophoretic delivery of a series of amino acid ester prodrugs of aciclovir as a means to enhance cutaneous, and more specifically, intraepidermal delivery of ACV. Chapter 2 compares cutaneous bioavailability following topical application of marketed aciclovir formulations to that achieved after iontophoresis of ACV or its amino acid ester prodrugs. Chapter 3 describes a successful investigation into the transcorneal and transscleral iontophoretic delivery of three amino acid ester prodrugs of aciclovir and as a means to increase ocular bioavailability of ACV. Chapter 4 describes a method to enhance topical passive topical delivery of aciclovir using a series of lipophilic aciclovir prodrugs in combination with supersaturation.
Keywords AciclovirProdrugIontophoresisSupersaturationAnalysisBiodistributionFast dissolving filmsHydrogelSkinEyeTopical delivery
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URN: urn:nbn:ch:unige-550222
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CHEN, Yong. Modulating physicochemical properties of drugs to optimise topical delivery: novel prodrugs of aciclovir to improve its cutaneous and ocular bioavailability using iontophoresis or supersaturated formulations. Université de Genève. Thèse, 2015. https://archive-ouverte.unige.ch/unige:55022

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Deposited on : 2015-04-01

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