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Title

Bordetella holmesii: an under-recognised Bordetella species

Authors
Emonet, Stéphane
Published in The Lancet Infectious Diseases. 2014, vol. 14, no. 6, p. 510-519
Abstract Bordetella holmesii, first described in 1995, is believed to cause both invasive infections (bacteraemia, meningitis, endocarditis, pericarditis, pneumonia, and arthritis) and pertussis-like symptoms. Infection with B holmesii is frequently misidentified as being with B pertussis, the cause of whooping cough, because routine diagnostic tests for pertussis are not species-specific. In this Review, we summarise knowledge about B holmesii diagnosis and treatment, and assess research needs. Although no fatal cases of B holmesii have been reported, associated invasive infections can cause substantial morbidities, even in previously healthy individuals. Antimicrobial treatment can be problematic because B holmesii's susceptibility to macrolides (used empirically to treat B pertussis) and third-generation cephalosporins (often used to treat invasive infections) is lower than would be expected. B holmesii's adaptation to human beings is continuing, and virulence might increase, causing the need for better diagnostic assays and epidemiological surveillance.
Keywords Bacteremia/diagnosis/epidemiology/microbiology/prevention & controlBordetella/genetics/isolation & purification/pathogenicityBordetella Infections/diagnosis/epidemiology/microbiology/prevention & controlDiagnosis, DifferentialGenome, Bacterial/geneticsHumansIncidenceMicrobial Sensitivity TestsPrevalenceSpecies SpecificityVirulence
Identifiers
PMID: 24721229
Full text
Article (Published version) (2.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Centre de Vaccinologie et d'Immunologie néonatale (177)
Recherche en infectiologie pédiatrique et en pédiatrie générale (853)
Citation
(ISO format)
PITTET, Laure et al. Bordetella holmesii: an under-recognised Bordetella species. In: The Lancet Infectious Diseases, 2014, vol. 14, n° 6, p. 510-519. doi: 10.1016/S1473-3099(14)70021-0 https://archive-ouverte.unige.ch/unige:54868

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Deposited on : 2015-03-27

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