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Title

Bordetella holmesii: an under-recognised Bordetella species

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Published in The Lancet Infectious Diseases. 2014, vol. 14, no. 6, p. 510-519
Abstract Bordetella holmesii, first described in 1995, is believed to cause both invasive infections (bacteraemia, meningitis, endocarditis, pericarditis, pneumonia, and arthritis) and pertussis-like symptoms. Infection with B holmesii is frequently misidentified as being with B pertussis, the cause of whooping cough, because routine diagnostic tests for pertussis are not species-specific. In this Review, we summarise knowledge about B holmesii diagnosis and treatment, and assess research needs. Although no fatal cases of B holmesii have been reported, associated invasive infections can cause substantial morbidities, even in previously healthy individuals. Antimicrobial treatment can be problematic because B holmesii's susceptibility to macrolides (used empirically to treat B pertussis) and third-generation cephalosporins (often used to treat invasive infections) is lower than would be expected. B holmesii's adaptation to human beings is continuing, and virulence might increase, causing the need for better diagnostic assays and epidemiological surveillance.
Keywords Bacteremia/diagnosis/epidemiology/microbiology/prevention & controlBordetella/genetics/isolation & purification/pathogenicityBordetella Infections/diagnosis/epidemiology/microbiology/prevention & controlDiagnosis, DifferentialGenome, Bacterial/geneticsHumansIncidenceMicrobial Sensitivity TestsPrevalenceSpecies SpecificityVirulence
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PMID: 24721229
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Article (Published version) (2.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research groups Centre de Vaccinologie et d'Immunologie néonatale (177)
Groupe Posfay-Barbe Clara (pédiatrie générale) (853)
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PITTET, Laure et al. Bordetella holmesii: an under-recognised Bordetella species. In: The Lancet Infectious Diseases, 2014, vol. 14, n° 6, p. 510-519. https://archive-ouverte.unige.ch/unige:54868

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Deposited on : 2015-03-27

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