Scientific article

Bordetella holmesii: an under-recognised Bordetella species

Published inLancet. Infectious diseases, vol. 14, no. 6, p. 510-519
Publication date2014

Bordetella holmesii, first described in 1995, is believed to cause both invasive infections (bacteraemia, meningitis, endocarditis, pericarditis, pneumonia, and arthritis) and pertussis-like symptoms. Infection with B holmesii is frequently misidentified as being with B pertussis, the cause of whooping cough, because routine diagnostic tests for pertussis are not species-specific. In this Review, we summarise knowledge about B holmesii diagnosis and treatment, and assess research needs. Although no fatal cases of B holmesii have been reported, associated invasive infections can cause substantial morbidities, even in previously healthy individuals. Antimicrobial treatment can be problematic because B holmesii's susceptibility to macrolides (used empirically to treat B pertussis) and third-generation cephalosporins (often used to treat invasive infections) is lower than would be expected. B holmesii's adaptation to human beings is continuing, and virulence might increase, causing the need for better diagnostic assays and epidemiological surveillance.

  • Bacteremia/diagnosis/epidemiology/microbiology/prevention & control
  • Bordetella/genetics/isolation & purification/pathogenicity
  • Bordetella Infections/diagnosis/epidemiology/microbiology/prevention & control
  • Diagnosis, Differential
  • Genome, Bacterial/genetics
  • Humans
  • Incidence
  • Microbial Sensitivity Tests
  • Prevalence
  • Species Specificity
  • Virulence
Citation (ISO format)
PITTET, Laure et al. Bordetella holmesii: an under-recognised Bordetella species. In: Lancet. Infectious diseases, 2014, vol. 14, n° 6, p. 510–519. doi: 10.1016/S1473-3099(14)70021-0
Main files (1)
Article (Published version)
ISSN of the journal1473-3099

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