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Scientific article
English

Nasopharyngeal microbiota in healthy children and pneumonia patients

Contributors

Sakwinska, Olga; Bastic Schmid, Viktoria; Berger, Bernard; Bruttin, Anne; Keitel, Kristina; Lepage, Mélissa; Moine, Deborah; Ngom Bru, Catherine; Brüssow, Harald; Gervaix, Alain

Published in

Journal of clinical microbiology, vol. 52, no. 5, p. 1590-1594

Publication date

2014

Abstract

Our study is the first to compare the nasopharyngeal microbiota of pediatric pneumonia patients and control children by 454 pyrosequencing. A distinct microbiota was associated with different pneumonia etiologies. Viral pneumonia was associated with a high abundance of the operational taxonomic unit (OTU) corresponding to Moraxella lacunata. Patients with nonviral pneumonia showed high abundances of OTUs of three typical bacterial pathogens, Streptococcus pneumoniae complex, Haemophilus influenzae complex, and Moraxella catarrhalis. Patients classified as having no definitive etiology harbored microbiota particularly enriched in the H. influenzae complex. We did not observe a commensal taxon specifically associated with health. The microbiota of the healthy nasopharynx was more diverse and contained a wider range of less abundant taxa.

Keywords

  • Adolescent
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Haemophilus Infections/diagnosis/microbiology
  • Haemophilus influenzae/genetics
  • Humans
  • Infant
  • Microbiota/genetics
  • Moraxella (Branhamella) catarrhalis/genetics
  • Moraxellaceae Infections/diagnosis/microbiology
  • Nasopharynx/microbiology/virology
  • Pneumococcal Infections/diagnosis/microbiology
  • Pneumonia/diagnosis/microbiology/virology
  • Prospective Studies
  • Respiratory Tract Infections/diagnosis/microbiology/virology
  • Streptococcus pneumoniae/genetics

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

SAKWINSKA, Olga et al. Nasopharyngeal microbiota in healthy children and pneumonia patients. In: Journal of clinical microbiology, 2014, vol. 52, n° 5, p. 1590–1594. doi: 10.1128/JCM.03280-13

Main files (1)

Article (Published version)

Corrections (1)

Erratum

Identifiers

Journal ISSN

0095-1137
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Technical informations

Creation

24/03/2015 13:46:00

First validation

24/03/2015 13:46:00

Update

14/03/2023 23:04:08

Status update

14/03/2023 23:04:07

Last indexation

30/10/2024 23:38:31
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