Nasopharyngeal microbiota in healthy children and pneumonia patients

Article Article scientifique Article Nasopharyngeal microbiota in healthy children and pneumonia patients eng 2014 author Sakwinska Olga author Bastic Schmid Viktoria author Berger Bernard 49092 author Bruttin Anne 83790 author Keitel Kristina author Lepage Mélissa author Moine Deborah author Ngom Bru Catherine author Brüssow Harald author Gervaix Alain 31715 1590-1594 10.1128/JCM.03280-13 24599973 0095-1137 Our study is the first to compare the nasopharyngeal microbiota of pediatric pneumonia patients and control children by 454 pyrosequencing. A distinct microbiota was associated with different pneumonia etiologies. Viral pneumonia was associated with a high abundance of the operational taxonomic unit (OTU) corresponding to Moraxella lacunata. Patients with nonviral pneumonia showed high abundances of OTUs of three typical bacterial pathogens, Streptococcus pneumoniae complex, Haemophilus influenzae complex, and Moraxella catarrhalis. Patients classified as having no definitive etiology harbored microbiota particularly enriched in the H. influenzae complex. We did not observe a commensal taxon specifically associated with health. The microbiota of the healthy nasopharynx was more diverse and contained a wider range of less abundant taxa. Adolescent Case-Control Studies Child Child, Preschool Haemophilus Infections/diagnosis/microbiology Haemophilus influenzae/genetics Humans Infant Microbiota/genetics Moraxella (Branhamella) catarrhalis/genetics Moraxellaceae Infections/diagnosis/microbiology Nasopharynx/microbiology/virology Pneumococcal Infections/diagnosis/microbiology Pneumonia/diagnosis/microbiology/virology Prospective Studies Respiratory Tract Infections/diagnosis/microbiology/virology Streptococcus pneumoniae/genetics Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 149 Etiologie des pneumonies et marqueurs inflammatoires chez l'enfant fébrile 183 Journal of clinical microbiology 52 5 61ba4897-8de9-4622-812d-366f8f8b27c9 Article (Published version) Restricted 1590-1594.pdf 261119 application/pdf 6357290c-d961-4f5b-bb64-01387037ed78 Erratum Restricted JCM.00417-19.pdf 158780 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Nasopharyngeal microbiota in healthy children and pneumonia patients	Journal of clinical microbiology			2014	528	1

Archive ouverte UNIGE

Berger, Bernard