UNIGE document Scientific Article - Review
previous document  unige:5406  next document
add to browser collection

NOX enzymes in the central nervous system: from signaling to disease

Published in Antioxidants & Redox Signaling. 2009, vol. 11, no. 10, p. 2481-504
Abstract Oxidative stress has been implicated in the pathogenesis of neurologic and psychiatric diseases. The brain is particularly vulnerable to oxidative damage due to high oxygen consumption, low antioxidant defense, and an abundance of oxidation-sensitive lipids. Production of reactive oxygen species (ROS) by mitochondria is generally thought to be the main cause of oxidative stress. However, a role for ROS-generating NADPH oxidase NOX enzymes has recently emerged. Activation of the phagocyte NADPH oxidase NOX2 has been studied mainly in microglia, where it plays a role in inflammation, but may also contribute to neuronal death in pathologic conditions. However, NOX-dependent ROS production can be due to the expression of other NOX isoforms, which are detected not only in microglia, but also in astrocytes and neurons. The physiologic and pathophysiologic roles of such NOX enzymes are only partially understood. In this review, we summarize the present knowledge about NOX enzymes in the central nervous system and their involvement in neurologic and psychiatric diseases.
Keywords AnimalsCentral Nervous System/anatomy & histology/enzymologyDisease Models, AnimalEnzyme Inhibitors/chemistry/metabolismHumansIsoenzymes/genetics/metabolismMolecular StructureNADPH Oxidase/antagonists & inhibitors/genetics/metabolismNervous System Diseases/enzymology/physiopathologyNeurodegenerative Diseases/enzymology/physiopathologyOxidative StressReactive Oxygen Species/metabolismSignal Transduction/physiology
PMID: 19309263
Full text
Article (Published version) (569 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Groupe Schaller Karl-Lothard (neurochirurgie) (851)
Radicaux libres et cellules souches embryonnaires (60)
(ISO format)
SORCE, Silvia, KRAUSE, Karl-Heinz. NOX enzymes in the central nervous system: from signaling to disease. In: Antioxidants & redox signaling, 2009, vol. 11, n° 10, p. 2481-504. doi: 10.1089/ARS.2009.2578 https://archive-ouverte.unige.ch/unige:5406

435 hits

0 download


Deposited on : 2010-03-12

Export document
Format :
Citation style :