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Title

Lactoferrin during lactation protects the immature hypoxic-ischemic rat brain
Authors
Van De Looij, Yohan
Ginet Puyal, Vanessa
Chatagner, Alexandra
Toulotte, Audrey
Somm, Emmanuel
Hüppi, Petra Susan
Sizonenko, Stéphane
Published in Annals of Clinical and Translational Neurology. 2014, vol. 1, no. 12, p. 955-67
Abstract Lactoferrin (Lf) is an iron-binding glycoprotein secreted in maternal milk presenting anti-inflammatory and antioxidant properties. It shows efficient absorption into the brain from nutritional source. Brain injury frequently resulting from cerebral hypoxia-ischemia (HI) has a high incidence in premature infants with ensuing neurodevelopmental disabilities. We investigated the neuroprotective effect of maternal nutritional supplementation with Lf during lactation in a rat model of preterm HI brain injury using magnetic resonance imaging (MRI), brain gene, and protein expression.
Identifiers
PMID: 25574471
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Article (Published version) (679 Kb) - public document Free access
Structures
Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group L'imagerie cérébrale (184)
Citation
(ISO format) 		VAN DE LOOIJ, Yohan et al. Lactoferrin during lactation protects the immature hypoxic-ischemic rat brain. In: Annals of Clinical and Translational Neurology, 2014, vol. 1, n° 12, p. 955-67. doi: 10.1002/acn3.138 https://archive-ouverte.unige.ch/unige:48454

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Deposited on : 2015-03-26

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