• Home
  1. Home
  2. Early Brain Activity Relates to Subsequent Brain Growth in Premature Infants
Scientific article
English

Early Brain Activity Relates to Subsequent Brain Growth in Premature Infants

Contributors

Benders, Manon J; Palmu, Kirsi; Menache, Caroline; Borradori Tolsa, Cristina; Lazeyras, François; Sizonenko, Stéphane; Dubois, Jessica; Vanhatalo, Sampsa; Hüppi, Petra Susan

Published in

Cerebral cortex, vol. 25, no. 9, p. 3014-3024

Publication date

2015

Abstract

Recent experimental studies have shown that early brain activity is crucial for neuronal survival and the development of brain networks; however, it has been challenging to assess its role in the developing human brain. We employed serial quantitative magnetic resonance imaging to measure the rate of growth in circumscribed brain tissues from preterm to term age, and compared it with measures of electroencephalographic (EEG) activity during the first postnatal days by 2 different methods. EEG metrics of functional activity were computed: EEG signal peak-to-peak amplitude and the occurrence of developmentally important spontaneous activity transients (SATs). We found that an increased brain activity in the first postnatal days correlates with a faster growth of brain structures during subsequent months until term age. Total brain volume, and in particular subcortical gray matter volume, grew faster in babies with less cortical electrical quiescence and with more SAT events. The present findings are compatible with the idea that (1) early cortical network activity is important for brain growth, and that (2) objective measures may be devised to follow early human brain activity in a biologically reasoned way in future research as well as during intensive care treatment.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

BENDERS, Manon J et al. Early Brain Activity Relates to Subsequent Brain Growth in Premature Infants. In: Cerebral cortex, 2015, vol. 25, n° 9, p. 3014–3024. doi: 10.1093/cercor/bhu097

Main files (1)

Article (Accepted version)

Identifiers

Journal ISSN

1047-3211
649views
0downloads

Technical informations

Creation

10/12/2014 17:59:00

First validation

10/12/2014 17:59:00

Update

14/03/2023 23:02:29

Status update

14/03/2023 23:02:29

Last indexation

30/10/2024 23:33:49
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated