Our main goal in this chapter is to determine whether decades of work in safety science and safety management have value for resolving controversies about GM agriculture. The implicit hypothesis is that there may be some commonalities between the safety issues posed by GM agriculture and other risky technologies, and potential benefits from using the toolbox of safety science that has been developed for more than 30 years in these other technological sectors. To avoid any misunderstanding, the discussion and points raised in this chapter do not cover the totality of the issues posed by genetic engineering.