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Scientific article
English

PNA-encoded chemical libraries

Published inCurrent opinion in chemical biology, vol. 26, p. 8-15
Publication date2015
Abstract

Peptide nucleic acid (PNA)-encoded chemical libraries along with DNA-encoded libraries have provided a powerful new paradigm for library synthesis and ligand discovery. PNA-encoding stands out for its compatibility with standard solid phase synthesis and the technology has been used to prepare libraries of peptides, heterocycles and glycoconjugates. Different screening formats have now been reported including selection-based and microarray-based methods that have yielded specific ligands against diverse target classes including membrane receptors, lectins and challenging targets such as Hsp70.

Citation (ISO format)
ZAMBALDO, Claudio, BARLUENGA BADIOLA, Sofia, WINSSINGER, Nicolas. PNA-encoded chemical libraries. In: Current opinion in chemical biology, 2015, vol. 26, p. 8–15. doi: 10.1016/j.cbpa.2015.01.005
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ISSN of the journal1367-5931
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Technical informations

Creation02/09/2015 11:12:00 AM
First validation02/09/2015 11:12:00 AM
Update time03/14/2023 10:50:33 PM
Status update03/14/2023 10:50:33 PM
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