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Anti-protein S antibodies following a varicella infection: detection, characterization and influence on thrombin generation

Regnault, V
de Groot, PG
Published in Journal of Thrombosis and Haemostasis. 2005, vol. 3, no. 6, p. 1243-9
Abstract Postinfectious purpura fulminans is a rare disease. Varicella is one of the precipitating conditions and we recently observed such a case. The 4-year-old child was found to have a severe transient protein S deficiency. By enzyme-linked immunosorbent assay and surface plasmon resonance we first demonstrated that anti-protein S antibodies were present and also transient. Next we characterized the epitopes against which these antibodies were directed and found that they predominantly recognized the N-terminal part of protein S. Finally we showed by thrombography a transient dramatic hypercoagulable state as a result of thrombin being unregulated by the dynamic protein C inhibitory system: in vitro thrombin generation, in response to a low concentration of tissue factor, was almost insensitive to activated protein C up to 25 nmol L(-1) on day 4 while it was normally sensitive on day 42. For the first time, we demonstrated a temporal relationship between protein S deficiency, antibodies to protein S and hypercoagulability, thus supporting the pathogenic role of these antibodies.
Keywords Autoantibodies/bloodChickenpox/blood/complicationsChild, PreschoolEnzyme-Linked Immunosorbent AssayEpitope MappingHumansMaleProtein S/immunologyProtein S Deficiency/etiology/virologyPurpura, Schoenlein-Henoch/etiology/virologySurface Plasmon ResonanceThrombin/biosynthesisThrombophilia/etiology/virologyTime Factors
PMID: 15946215
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Research group Anticorps antiphospholipides (12)
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REGNAULT, V et al. Anti-protein S antibodies following a varicella infection: detection, characterization and influence on thrombin generation. In: Journal of Thrombosis and Haemostasis, 2005, vol. 3, n° 6, p. 1243-9. doi: 10.1111/j.1538-7836.2005.01270.x https://archive-ouverte.unige.ch/unige:46631

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Deposited on : 2015-02-12

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