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Title

Long-term expression of fibrogenic cytokines in radiation-induced damage to the internal anal sphincter

Authors
Hennig, R
Brigstock, D R
Friess, H
Published in Swiss Surgery. 2003, vol. 9, no. 4, p. 193-7
Abstract There is accumulating evidence, both quantitative and qualitative, that pelvic irradiation affects anorectal function. However, the molecular mechanisms responsible for radiation-induced damage to the anal sphincter remain unclear.
Keywords Adenocarcinoma/radiotherapy/surgeryAgedAged, 80 and overAnal Canal/pathology/radiation effectsConnective Tissue Growth FactorDisease ProgressionFibrosis/pathology/surgeryHumansImmediate-Early Proteins/analysisImmunoenzyme TechniquesIntercellular Signaling Peptides and Proteins/analysisMaleMuscle, Smooth/pathology/radiation effectsNeoplasms, Radiation-Induced/surgeryNeoplasms, Second Primary/surgeryProstatic Neoplasms/radiotherapyRadiation Injuries/pathologyRectal Neoplasms/surgeryRectum/pathology/radiation effects/surgeryReoperationTransforming Growth Factor beta/analysisTransforming Growth Factor beta1
Identifiers
PMID: 12974179
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Article (Published version) (1.4 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Chirurgie viscérale (104)
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GERVAZ, Pascal et al. Long-term expression of fibrogenic cytokines in radiation-induced damage to the internal anal sphincter. In: Swiss Surgery, 2003, vol. 9, n° 4, p. 193-7. https://archive-ouverte.unige.ch/unige:45070

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Deposited on : 2015-01-13

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