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Title

Relapse of Tropheryma whipplei endocarditis treated by trimethoprim/sulfamethoxazole, cured by hydroxychloroquine plus doxycycline

Authors
Lagier, Jean-Christophe
Raoult, Didier
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Published in International Journal of Infectious Diseases. 2014, vol. 30C, p. 17-19
Abstract The best treatment for Tropheryma whipplei infections is controversial. We report a patient who suffered from T. whipplei aortic native valve endocarditis that relapsed despite surgery and four weeks of intravenous ceftriaxone followed by several months of oral trimethoprim/sulfamethoxazole. Cure was achieved after replacement of the prosthesis with a homograft and 18 months of oral doxycycline-hydroxychloroquine. We discuss the need for a change in treatment guidelines for T. whipplei infections.
Identifiers
PMID: 25461667
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Article (Published version) (816 Kb) - public document Free access
Structures
Research groups Chirurgie cardio-vasculaire (105)
Groupe Harbarth Stephan (Staphylocoques dorés résistants à la méthicilline) (866)
Analyse génomique et fonctionnelle du staphylocoque doré (604)
Quorom-sensing et gènes de virulence (301)
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(ISO format)
EMONET, Stéphane Paul et al. Relapse of Tropheryma whipplei endocarditis treated by trimethoprim/sulfamethoxazole, cured by hydroxychloroquine plus doxycycline. In: International Journal of Infectious Diseases, 2014, vol. 30C, p. 17-19. https://archive-ouverte.unige.ch/unige:44776

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Deposited on : 2015-01-09

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