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Title

Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis

Authors
Raschi, Elena
Testoni, Cinzia
Mallone, Roberto
Gabrielli, Armando
Facchini, Andrea
Del Papa, Nicoletta
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Published in Arthritis and Rheumatism. 2002, vol. 46, no. 6, p. 1602-13
Abstract Fibroblasts play a major role in the development of systemic sclerosis (SSc), and the occurrence of serum autoantibodies reacting with fibroblast plasma membrane antigens in SSc has been reported. This study was undertaken to investigate whether IgG from SSc sera that react with human fibroblasts modulates the fibroblasts' function.
Keywords AdultAgedAntirheumatic Agents/pharmacologyAutoantibodies/immunology/pharmacologyCell Adhesion/immunologyCells, CulturedFemaleFibroblasts/cytology/immunologyFlow CytometryGene Expression/drug effects/immunologyHumansImmunoglobulin G/immunology/pharmacologyIntercellular Adhesion Molecule-1/geneticsInterleukin 1 Receptor Antagonist ProteinInterleukin-1/genetics/immunologyInterleukin-6/genetics/immunologyMaleMiddle AgedPhenotypeRNA, Messenger/metabolismScleroderma, Systemic/epidemiology/immunologySeroepidemiologic StudiesSialoglycoproteins/pharmacologyUp-Regulation/drug effects/immunology
Identifiers
PMID: 12115192
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Article (Published version) (1.4 MB) - public document Free access
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Research group La matrice extracellulaire (651)
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CHIZZOLINI, Carlo et al. Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis. In: Arthritis and Rheumatism, 2002, vol. 46, n° 6, p. 1602-13. https://archive-ouverte.unige.ch/unige:44721

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Deposited on : 2015-01-08

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