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Professional article
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English

Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis

Published inArthritis and rheumatism, vol. 46, no. 6, p. 1602-1613
Publication date2002
Abstract

Fibroblasts play a major role in the development of systemic sclerosis (SSc), and the occurrence of serum autoantibodies reacting with fibroblast plasma membrane antigens in SSc has been reported. This study was undertaken to investigate whether IgG from SSc sera that react with human fibroblasts modulates the fibroblasts' function.

Keywords
  • Adult
  • Aged
  • Antirheumatic Agents/pharmacology
  • Autoantibodies/immunology/pharmacology
  • Cell Adhesion/immunology
  • Cells, Cultured
  • Female
  • Fibroblasts/cytology/immunology
  • Flow Cytometry
  • Gene Expression/drug effects/immunology
  • Humans
  • Immunoglobulin G/immunology/pharmacology
  • Intercellular Adhesion Molecule-1/genetics
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1/genetics/immunology
  • Interleukin-6/genetics/immunology
  • Male
  • Middle Aged
  • Phenotype
  • RNA, Messenger/metabolism
  • Scleroderma, Systemic/epidemiology/immunology
  • Seroepidemiologic Studies
  • Sialoglycoproteins/pharmacology
  • Up-Regulation/drug effects/immunology
Citation (ISO format)
CHIZZOLINI, Carlo et al. Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis. In: Arthritis and rheumatism, 2002, vol. 46, n° 6, p. 1602–1613. doi: 10.1002/art.10361
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0004-3591
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295downloads

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