Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis

Chizzolini, Carlo; Raschi, Elena; Rezzonico, Roger Michel; Testoni, Cinzia; Mallone, Roberto; Gabrielli, Armando; Facchini, Andrea; Del Papa, Nicoletta; Borghi, Maria Orietta; Dayer, Jean-Michel; Meroni, Pier Luigi

doi:10.1002/art.10361

Professional article

English

Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis

ContributorsChizzolini, Carlo; Raschi, Elena; Rezzonico, Roger Michel; Testoni, Cinzia; Mallone, Roberto; Gabrielli, Armando; Facchini, Andrea; Del Papa, Nicoletta; Borghi, Maria Orietta; Dayer, Jean-Michel; Meroni, Pier Luigi

Published inArthritis and rheumatism, vol. 46, no. 6, p. 1602-1613

Publication date2002

Abstract

Fibroblasts play a major role in the development of systemic sclerosis (SSc), and the occurrence of serum autoantibodies reacting with fibroblast plasma membrane antigens in SSc has been reported. This study was undertaken to investigate whether IgG from SSc sera that react with human fibroblasts modulates the fibroblasts' function.

Keywords

Adult
Aged
Antirheumatic Agents/pharmacology
Autoantibodies/immunology/pharmacology
Cell Adhesion/immunology
Cells, Cultured
Female
Fibroblasts/cytology/immunology
Flow Cytometry
Gene Expression/drug effects/immunology
Humans
Immunoglobulin G/immunology/pharmacology
Intercellular Adhesion Molecule-1/genetics
Interleukin 1 Receptor Antagonist Protein
Interleukin-1/genetics/immunology
Interleukin-6/genetics/immunology
Male
Middle Aged
Phenotype
RNA, Messenger/metabolism
Scleroderma, Systemic/epidemiology/immunology
Seroepidemiologic Studies
Sialoglycoproteins/pharmacology
Up-Regulation/drug effects/immunology

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

La matrice extracellulaire (651)

Citation (ISO format)

CHIZZOLINI, Carlo et al. Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis. In: Arthritis and rheumatism, 2002, vol. 46, n° 6, p. 1602–1613. doi: 10.1002/art.10361

Article (Published version)

Identifiers

PID : unige:44721
DOI : 10.1002/art.10361
PMID : 12115192

Journal ISSN0004-3591

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Update14/03/2023 22:36:58

Status update14/03/2023 22:36:58

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Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis

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