Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis

Article Article professionnel Article Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis eng 2002 author Chizzolini Carlo 93910 author Raschi Elena author Rezzonico Roger Michel 110209 author Testoni Cinzia author Mallone Roberto author Gabrielli Armando author Facchini Andrea author Del Papa Nicoletta author Borghi Maria Orietta author Dayer Jean-Michel 25468 author Meroni Pier Luigi 1602-1613 10.1002/art.10361 12115192 0004-3591 Fibroblasts play a major role in the development of systemic sclerosis (SSc), and the occurrence of serum autoantibodies reacting with fibroblast plasma membrane antigens in SSc has been reported. This study was undertaken to investigate whether IgG from SSc sera that react with human fibroblasts modulates the fibroblasts' function. Adult Aged Antirheumatic Agents/pharmacology Autoantibodies/immunology/pharmacology Cell Adhesion/immunology Cells, Cultured Female Fibroblasts/cytology/immunology Flow Cytometry Gene Expression/drug effects/immunology Humans Immunoglobulin G/immunology/pharmacology Intercellular Adhesion Molecule-1/genetics Interleukin 1 Receptor Antagonist Protein Interleukin-1/genetics/immunology Interleukin-6/genetics/immunology Male Middle Aged Phenotype RNA, Messenger/metabolism Scleroderma, Systemic/epidemiology/immunology Seroepidemiologic Studies Sialoglycoproteins/pharmacology Up-Regulation/drug effects/immunology Dewey 616 56 Département de médecine 221 false 385 La matrice extracellulaire 651 Arthritis and rheumatism 46 6 bb4e8778-6bb2-4f2e-92aa-ead472a62220 Article (Published version) Public Chizzolini C - ARTHRITIS & RHEUMATISM - 2002.pdf 1506306 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis	Arthritis and rheumatism			2002	621	586

Archive ouverte UNIGE

Rezzonico, Roger Michel