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Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha

Published inArthritis and rheumatism, vol. 48, no. 9, p. 2593-2604
Publication date2003
Abstract

In systemic sclerosis (SSc; scleroderma), T cells infiltrate organs undergoing fibrotic changes and may participate in dysregulated production of collagen by fibroblasts. The objective of this study was to functionally characterize T cells infiltrating skin lesions in early SSc and investigate their capacity to affect production of type I collagen and interstitial collagenase (matrix metalloproteinase 1 [MMP-1]) by dermal fibroblasts.

Keywords
  • Adult
  • Cell Communication/immunology
  • Cell Line
  • Cell Membrane/immunology/metabolism
  • Collagen/genetics/metabolism
  • Dermis/cytology/immunology/metabolism
  • Female
  • Fibroblasts/cytology/immunology/metabolism
  • Gene Expression/immunology
  • Humans
  • Interferon-gamma/biosynthesis
  • Interleukin-4/biosynthesis
  • Male
  • Matrix Metalloproteinase 1/genetics/metabolism
  • Middle Aged
  • RNA, Messenger/analysis
  • Scleroderma, Systemic/immunology/metabolism
  • T-Lymphocyte Subsets/cytology/immunology
  • Th2 Cells/cytology/immunology/metabolism
  • Tumor Necrosis Factor-alpha/immunology/metabolism
Citation (ISO format)
CHIZZOLINI, Carlo et al. Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha. In: Arthritis and rheumatism, 2003, vol. 48, n° 9, p. 2593–2604. doi: 10.1002/art.11129
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Article (Published version)
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ISSN of the journal0004-3591
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