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Title

Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha

Authors
Tyndall, Alan
Akesson, Anita
Scheja, Agneta
Published in Arthritis and Rheumatism. 2003, vol. 48, no. 9, p. 2593-604
Abstract In systemic sclerosis (SSc; scleroderma), T cells infiltrate organs undergoing fibrotic changes and may participate in dysregulated production of collagen by fibroblasts. The objective of this study was to functionally characterize T cells infiltrating skin lesions in early SSc and investigate their capacity to affect production of type I collagen and interstitial collagenase (matrix metalloproteinase 1 [MMP-1]) by dermal fibroblasts.
Keywords AdultCell Communication/immunologyCell LineCell Membrane/immunology/metabolismCollagen/genetics/metabolismDermis/cytology/immunology/metabolismFemaleFibroblasts/cytology/immunology/metabolismGene Expression/immunologyHumansInterferon-gamma/biosynthesisInterleukin-4/biosynthesisMaleMatrix Metalloproteinase 1/genetics/metabolismMiddle AgedRNA, Messenger/analysisScleroderma, Systemic/immunology/metabolismT-Lymphocyte Subsets/cytology/immunologyTh2 Cells/cytology/immunology/metabolismTumor Necrosis Factor-alpha/immunology/metabolism
Identifiers
PMID: 13130479
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Article (Published version) (392 Kb) - public document Free access
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Research group La matrice extracellulaire (651)
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CHIZZOLINI, Carlo et al. Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha. In: Arthritis and Rheumatism, 2003, vol. 48, n° 9, p. 2593-604. https://archive-ouverte.unige.ch/unige:44716

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Deposited on : 2015-01-08

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