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Title

Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha
Authors
Chizzolini, Carlo
Parel, Yann
De Luca, Carmelina
Tyndall, Alan
Akesson, Anita
Scheja, Agneta
Dayer, Jean-Michel
Published in Arthritis and rheumatism. 2003, vol. 48, no. 9, p. 2593-604
Abstract In systemic sclerosis (SSc; scleroderma), T cells infiltrate organs undergoing fibrotic changes and may participate in dysregulated production of collagen by fibroblasts. The objective of this study was to functionally characterize T cells infiltrating skin lesions in early SSc and investigate their capacity to affect production of type I collagen and interstitial collagenase (matrix metalloproteinase 1 [MMP-1]) by dermal fibroblasts.
Keywords Adult — Cell Communication/immunology — Cell Line — Cell Membrane/immunology/metabolism — Collagen/genetics/metabolism — Dermis/cytology/immunology/metabolism — Female — Fibroblasts/cytology/immunology/metabolism — Gene Expression/immunology — Humans — Interferon-gamma/biosynthesis — Interleukin-4/biosynthesis — Male — Matrix Metalloproteinase 1/genetics/metabolism — Middle Aged — RNA, Messenger/analysis — Scleroderma, Systemic/immunology/metabolism — T-Lymphocyte Subsets/cytology/immunology — Th2 Cells/cytology/immunology/metabolism — Tumor Necrosis Factor-alpha/immunology/metabolism
Identifiers
PMID: 13130479
Full text
Article (Published version) (392 Kb) - public document Free access
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Research group La matrice extracellulaire (651)
Citation
(ISO format) 		CHIZZOLINI, Carlo et al. Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha. In: Arthritis and Rheumatism, 2003, vol. 48, n° 9, p. 2593-604. doi: 10.1002/art.11129 https://archive-ouverte.unige.ch/unige:44716

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Deposited on : 2015-01-08

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