Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha

Chizzolini, Carlo; Parel, Yann; De Luca, Carmelina; Tyndall, Alan; Akesson, Anita; Scheja, Agneta; Dayer, Jean-Michel

doi:10.1002/art.11129

Professional article

English

Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha

ContributorsChizzolini, Carlo; Parel, Yann; De Luca, Carmelina; Tyndall, Alan; Akesson, Anita; Scheja, Agneta; Dayer, Jean-Michel

Published inArthritis and rheumatism, vol. 48, no. 9, p. 2593-2604

Publication date2003

Abstract

In systemic sclerosis (SSc; scleroderma), T cells infiltrate organs undergoing fibrotic changes and may participate in dysregulated production of collagen by fibroblasts. The objective of this study was to functionally characterize T cells infiltrating skin lesions in early SSc and investigate their capacity to affect production of type I collagen and interstitial collagenase (matrix metalloproteinase 1 [MMP-1]) by dermal fibroblasts.

Keywords

Adult
Cell Communication/immunology
Cell Line
Cell Membrane/immunology/metabolism
Collagen/genetics/metabolism
Dermis/cytology/immunology/metabolism
Female
Fibroblasts/cytology/immunology/metabolism
Gene Expression/immunology
Humans
Interferon-gamma/biosynthesis
Interleukin-4/biosynthesis
Male
Matrix Metalloproteinase 1/genetics/metabolism
Middle Aged
RNA, Messenger/analysis
Scleroderma, Systemic/immunology/metabolism
T-Lymphocyte Subsets/cytology/immunology
Th2 Cells/cytology/immunology/metabolism
Tumor Necrosis Factor-alpha/immunology/metabolism

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

La matrice extracellulaire (651)

Citation (ISO format)

CHIZZOLINI, Carlo et al. Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha. In: Arthritis and rheumatism, 2003, vol. 48, n° 9, p. 2593–2604. doi: 10.1002/art.11129

Article (Published version)

Identifiers

PID : unige:44716
DOI : 10.1002/art.11129
PMID : 13130479

Journal ISSN0004-3591

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Creation09/12/2014 13:11:00

First validation09/12/2014 13:11:00

Update time14/03/2023 22:36:55

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Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha

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