Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha

Article Article professionnel Article Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha eng 2003 author Chizzolini Carlo 93910 author Parel Yann 88860 author De Luca Carmelina 28223 author Tyndall Alan author Akesson Anita author Scheja Agneta author Dayer Jean-Michel 25468 2593-2604 10.1002/art.11129 13130479 0004-3591 In systemic sclerosis (SSc; scleroderma), T cells infiltrate organs undergoing fibrotic changes and may participate in dysregulated production of collagen by fibroblasts. The objective of this study was to functionally characterize T cells infiltrating skin lesions in early SSc and investigate their capacity to affect production of type I collagen and interstitial collagenase (matrix metalloproteinase 1 [MMP-1]) by dermal fibroblasts. Adult Cell Communication/immunology Cell Line Cell Membrane/immunology/metabolism Collagen/genetics/metabolism Dermis/cytology/immunology/metabolism Female Fibroblasts/cytology/immunology/metabolism Gene Expression/immunology Humans Interferon-gamma/biosynthesis Interleukin-4/biosynthesis Male Matrix Metalloproteinase 1/genetics/metabolism Middle Aged RNA, Messenger/analysis Scleroderma, Systemic/immunology/metabolism T-Lymphocyte Subsets/cytology/immunology Th2 Cells/cytology/immunology/metabolism Tumor Necrosis Factor-alpha/immunology/metabolism Dewey 616 56 Département de médecine 221 false 385 La matrice extracellulaire 651 Arthritis and rheumatism 48 9 75a62bd1-eaa7-4421-be6e-5e9ac03182da Article (Published version) Public Chizzolini C - ARTHRITIS & RHEUMATISM - 2003.pdf 401908 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha	Arthritis and rheumatism			2003	1,034	645

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De Luca, Carmelina