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Title

Islet of Langerhans transplantation for the treatment of type 1 diabetes

Authors
Mathe, Z
Published in Swiss Surgery. 2003, vol. 9, no. 5, p. 242-6
Abstract Islet of Langerhans transplantation is gaining recognition as a therapy for type 1 diabetes. The procedure involves enzymatic digestion of the pancreatic tissue, purification of the islets from the exocrine tissue, infusion of the islets into the portal vein and implantation in the liver. Until 1999, and overall rate of insulin independence of 14% at one year was reported in the International Islet Transplant Registry. The results of the "Edmonton protocol" since 2000 were a breakthrough in the field, with reports of 80% insulin independence at 1-year after solitary islet transplantation in non uremic patients with brittle type 1 diabetes. A rapamycin-based, steroid-free, islet-sparing immunosuppressive regimen was designed and the problem of the insufficient islet mass was tackled by sequential infusions of islets isolated from at least two pancreatic. The University of Geneva has been involved in clinical islet transplantation since 1992, and has performed 51 allogeneic and 17 autologous. Twenty-one patients have been transplanted in Geneva since 2002. They were five solitary islet transplants, 14 islet after kidney transplants and two simultaneous islet-kidney (SIK) recipients. Insulin independence was achieved in 67%.
Keywords Diabetes Mellitus, Type 1/mortality/surgeryDrug Therapy, CombinationFollow-Up StudiesHumansImmunosuppressive Agents/adverse effects/therapeutic useInsulin/secretionIslets of Langerhans Transplantation/methodsKidney Transplantation/methodsSirolimus/adverse effects/therapeutic useSwitzerlandTissue and Organ Harvesting/methodsTransplantation, Heterotopic/methods
Identifiers
PMID: 14601328
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Article (Published version) (1.9 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Chirurgie viscérale (104)
La transplantation d'îlots de Langerhans (623)
Cultures cellulaires et transplantations (519)
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(ISO format)
BUCHER, Pascal Alain Robert et al. Islet of Langerhans transplantation for the treatment of type 1 diabetes. In: Swiss Surgery, 2003, vol. 9, n° 5, p. 242-6. https://archive-ouverte.unige.ch/unige:43973

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Deposited on : 2014-12-19

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