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Title

A multicenter phase II trial (SAKK 36/06) of single-agent everolimus (RAD001) in patients with relapsed or refractory mantle cell lymphoma

Authors
Renner, Christoph
Zinzani, Pier Luigi
Gressin, Rémy
Klingbiel, Dirk
Hitz, Felicitas
Bargetzi, Mario
Mingrone, Walter
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Published in Haematologica. 2012, vol. 97, no. 7, p. 1085-91
Abstract Mantle cell lymphoma accounts for 6% of all B-cell lymphomas and is generally incurable. It is characterized by the translocation t(11;14) leading to cyclin D1 over-expression. Cyclin D1 is downstream of the mammalian target of rapamycin threonine kinase and can be effectively blocked by mammalian target of rapamycin inhibitors. We set out to examine the single agent activity of the orally available mammalian target of rapamycin inhibitor everolimus in a prospective, multicenter trial in patients with relapsed or refractory mantle cell lymphoma (NCT00516412).
Keywords AdultAgedAged, 80 and overDisease-Free SurvivalDrug Administration ScheduleFemaleHumansLymphoma, Mantle-Cell/drug therapy/mortalityMaleMiddle AgedNeoplasm Proteins/antagonists & inhibitorsNeoplasm StagingProspective StudiesProtein Kinase Inhibitors/administration & dosage/adverse effectsRecurrenceRemission InductionSirolimus/administration & dosage/adverse effects/analogs & derivativesTOR Serine-Threonine Kinases/antagonists & inhibitors
Identifiers
PMID: 22315486
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Article (Published version) (705 Kb) - public document Free access
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Research group Immunothérapie des cancers (42)
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RENNER, Christoph et al. A multicenter phase II trial (SAKK 36/06) of single-agent everolimus (RAD001) in patients with relapsed or refractory mantle cell lymphoma. In: Haematologica, 2012, vol. 97, n° 7, p. 1085-91. https://archive-ouverte.unige.ch/unige:43570

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Deposited on : 2014-12-16

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