Two Intrinsic Coupling Types for Resting-State Integration in the Human Brain

Guggisberg, Adrian; Rizk, Sviatlana; Ptak, Radek; Di Pietro Peralta-Bachman, Marie; Saj, Arnaud; Lazeyras, François; Lövblad, Karl-Olof; Schnider, Armin; Pignat, Jean-Michel

doi:10.1007/s10548-014-0394-2

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Title		Two Intrinsic Coupling Types for Resting-State Integration in the Human Brain
Authors		Guggisberg, Adrian Rizk, Sviatlana Ptak, Radek Di Pietro Peralta-Bachman, Marie Saj, Arnaud Lazeyras, François Lövblad, Karl-Olof Schnider, Armin Pignat, Jean-Michel show all authors [1 - 9]
Published in		Brain topography. 2015, vol. 28, p. 318-29
Abstract		Recent findings indicate that synchronous neural activity at rest influences human performance in subsequent tasks. Synchronization can occur in form of phase coupling or amplitude correlation. It is unknown whether these coupling types have differing behavioral significance at rest. To address this, we performed resting-state electroencephalography (EEG) and source connectivity analysis in several populations of healthy subjects and patients with brain lesions. We systematically compared different types and frequencies of neural synchronization and investigated their association with behavioral performance in verbal and spatial attention tasks. Behavioral performance could be consistently predicted by two distinct resting-state coupling patterns: (1) amplitude envelope correlation of beta activity between homologous areas of both hemispheres, (2) lagged phase synchronization in EEG alpha activity between a brain area and the entire cortex. A disruption of these coupling patterns was also associated with neurological deficits in patients with stroke lesions. This suggests the existence of two distinct network systems responsible for resting-state integration. Lagged phase synchronization in the alpha band is associated with global interaction across networks while amplitude envelope correlation seems to be behaviorally relevant for interactions within networks and between hemispheres. These two coupling types may therefore provide complementary insights on brain physiology and pathology.
Identifiers		DOI: 10.1007/s10548-014-0394-2 PMID: 25182143
Full text		Article (Published version) (1.2 MB) - Limited access to UNIGE Article (Accepted version) (770 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Research groups		Amnésie (289) Groupe Lazeyras Francois (IRM fonctionnelle et métabolique) (539) Ischémie cérébrale et connectivité (801) Neuropsychologie et neurologie comportementale (951) Neuroréhabilitation assistée par imagerie (910)
Citation (ISO format)		GUGGISBERG, Adrian et al. Two Intrinsic Coupling Types for Resting-State Integration in the Human Brain. In: Brain topography, 2015, vol. 28, p. 318-29. doi: 10.1007/s10548-014-0394-2 https://archive-ouverte.unige.ch/unige:42249