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UniProtKB/Swiss-Prot manual and automated annotation of complete proteomes: the Dictyostelium discoideum case study

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Published in Appel, R.D, & Feytmans, E. Bioinformatics: A Swiss Perspective. Singapore: World Scientific Publishing, Singapore. 2009, p. 149-168
Abstract The main goal of the Swiss-Prot section of the UniProt Knowledgebase (UniProtKB) is to ensure the presence of high-quality annotation for representative members of most protein families, and Swiss-Prot curators mainly concentrate their efforts on proteins from model organisms. Dictyostelium discoideum is one of the few organisms selected by the National Institutes of Health (NIH) as suitable for functional analysis of sequenced genes, and researchers working on this model benefit from the existence of dictyBase, the official and inestimable resource for Dictyostelium discoideum genome annotation. Yet, annotation of the Dictyostelium discoideum proteome was absent from UniProt’s priority list until the launch of a collaboration between dictyBase and UniProtKB. This chapter reviews the Swiss-Prot annotation process by taking examples from the recently annotated part of the Dictyostelium discoideum proteome, and shows how fruitful a collaboration can be between a model organism database and the generalist database UniProtKB.
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ISBN: 978-981-283-877-3
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Book chapter (Author postprint) (326 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research groups Calipho (80)
Swiss-Prot Research Group
Swiss Institute of Bioinformatics
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BAIROCH, Amos Marc, LANE, Lydie. UniProtKB/Swiss-Prot manual and automated annotation of complete proteomes: the Dictyostelium discoideum case study. In: Appel, R.D, & Feytmans, E. (Ed.). Bioinformatics: a Swiss Perspective. Singapore : World Scientific Publishing, Singapore, 2009. p. 149-168. https://archive-ouverte.unige.ch/unige:42191

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Deposited on : 2014-11-26

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