Short-term immunosuppression reduces fibrotic cellular infiltration around barium-M-alginate microbeads injected intraportally

Mathe, Z; Bucher, Pascal Alain Robert; Bosco, Domenico; Andres, Axel; Fux, Catherine; Toso, Christian; Oberholzer, José; Wandrey, C.; Sainz-Vidal, D; Espinosa, D; Buehler, Leo Hans; Morel, Philippe; Berney, Thierry

doi:10.1016/j.transproceed.2004.04.021

Scientific article

English

Short-term immunosuppression reduces fibrotic cellular infiltration around barium-M-alginate microbeads injected intraportally

ContributorsMathe, Z; Bucher, Pascal Alain Robert; Bosco, Domenico; Andres, Axel; Fux, Catherine; Toso, Christian

; Oberholzer, José; Wandrey, C.; Sainz-Vidal, D; Espinosa, D; Buehler, Leo Hans; Morel, Philippe; Berney, Thierry

Published inTransplantation proceedings, vol. 36, no. 4, p. 1199-1200

Publication date2004

Abstract

One of the major barriers affecting the viability of encapsulated islets is pericapsular fibrotic infiltration (PFI). This study aimed to design strategies to reduce PFI around intraportally injected alginate microbeads.

Keywords

Alginates
Animals
Capsules
Fibrosis/prevention & control
Glucuronic Acid
Hexuronic Acids
Immunosuppression/methods
Immunosuppressive Agents/therapeutic use
Islets of Langerhans/cytology
Islets of Langerhans Transplantation/immunology/methods
Portal System
Rats
Rats, Inbred Lew

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Citation (ISO format)

MATHE, Z et al. Short-term immunosuppression reduces fibrotic cellular infiltration around barium-M-alginate microbeads injected intraportally. In: Transplantation proceedings, 2004, vol. 36, n° 4, p. 1199–1200. doi: 10.1016/j.transproceed.2004.04.021

Article (Published version)

Identifiers

PID : unige:41776
DOI : 10.1016/j.transproceed.2004.04.021
PMID : 15194415

Journal ISSN0041-1345

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Short-term immunosuppression reduces fibrotic cellular infiltration around barium-M-alginate microbeads injected intraportally

One of the major barriers affecting the viability of encapsulated islets is pericapsular fibrotic infiltration (PFI). This study aimed to design strategies to reduce PFI around intraportally injected alginate microbeads.

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