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Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1)

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Published in Cancer Letters. 2004, vol. 203, no. 1, p. 25-33
Abstract Peroxisome proliferator-activated receptors (PPARs) alpha,beta/delta and gamma are fatty acid sensitive transcription factors that have been implicated in colorectal cancer. To better understand their role, we studied the expression levels of all PPAR-isoforms and transcriptional partners such as the retinoid X receptor alpha (RXRalpha) and PPARgamma-coactivator-1 (PGC-1) by means of real-time PCR in 17 patients with colon cancer. While a heterogeneous pattern was observed for the expression level of the PPAR-isoforms alpha,beta/delta and gamma, the coactivator PGC-1 was significantly decreased in 15 of 17 tumors. Taken together our data suggest that the transcriptional activity of PPARgamma may not only be decreased by mutation but also by downregulation of the coactivator PGC-1 of PPARgamma.
Keywords AdultAgedColonic Neoplasms/genetics/metabolismDown-RegulationFemaleHumansMaleMiddle AgedMutationProtein Isoforms/metabolismReceptors, Cytoplasmic and Nuclear/genetics/metabolismReceptors, Retinoic Acid/metabolismRetinoid X ReceptorsReverse Transcriptase Polymerase Chain ReactionTranscription Factors/genetics/metabolism
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PMID: 14670614
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Research group Chirurgie viscérale (104)
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FEILCHENFELDT, Jonas Walter et al. Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1). In: Cancer Letters, 2004, vol. 203, n° 1, p. 25-33. https://archive-ouverte.unige.ch/unige:41285

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Deposited on : 2014-10-29

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