Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1)

Feilchenfeldt, Jonas Walter; Brundler, Marie-Anne; Soravia, Claudio; Totsch, Martin; Meier, Christoph

doi:10.1016/j.canlet.2003.08.024

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Title		Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1)
Authors		Feilchenfeldt, Jonas Walter Brundler, Marie-Anne Soravia, Claudio Totsch, Martin Meier, Christoph
Published in		Cancer letters. 2004, vol. 203, no. 1, p. 25-33
Abstract		Peroxisome proliferator-activated receptors (PPARs) alpha,beta/delta and gamma are fatty acid sensitive transcription factors that have been implicated in colorectal cancer. To better understand their role, we studied the expression levels of all PPAR-isoforms and transcriptional partners such as the retinoid X receptor alpha (RXRalpha) and PPARgamma-coactivator-1 (PGC-1) by means of real-time PCR in 17 patients with colon cancer. While a heterogeneous pattern was observed for the expression level of the PPAR-isoforms alpha,beta/delta and gamma, the coactivator PGC-1 was significantly decreased in 15 of 17 tumors. Taken together our data suggest that the transcriptional activity of PPARgamma may not only be decreased by mutation but also by downregulation of the coactivator PGC-1 of PPARgamma.
Keywords		Adult — Aged — Colonic Neoplasms/genetics/metabolism — Down-Regulation — Female — Humans — Male — Middle Aged — Mutation — Protein Isoforms/metabolism — Receptors, Cytoplasmic and Nuclear/genetics/metabolism — Receptors, Retinoic Acid/metabolism — Retinoid X Receptors — Reverse Transcriptase Polymerase Chain Reaction — Transcription Factors/genetics/metabolism
Identifiers		DOI: 10.1016/j.canlet.2003.08.024 PMID: 14670614
Full text		Article (Published version) (259 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research groups		Chirurgie viscérale (104) Chirurgie viscérale (HUG)
Citation (ISO format)		FEILCHENFELDT, Jonas Walter et al. Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1). In: Cancer letters, 2004, vol. 203, n° 1, p. 25-33. doi: 10.1016/j.canlet.2003.08.024 https://archive-ouverte.unige.ch/unige:41285

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Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1)