Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1)

Article Article scientifique Article Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1) eng 2004 author Feilchenfeldt Jonas Walter 82428 author Brundler Marie-Anne 526487 author Soravia Claudio 126700 author Totsch Martin 513725 author Meier Christoph 28951 25-33 10.1016/j.canlet.2003.08.024 14670614 0304-3835 Peroxisome proliferator-activated receptors (PPARs) alpha,beta/delta and gamma are fatty acid sensitive transcription factors that have been implicated in colorectal cancer. To better understand their role, we studied the expression levels of all PPAR-isoforms and transcriptional partners such as the retinoid X receptor alpha (RXRalpha) and PPARgamma-coactivator-1 (PGC-1) by means of real-time PCR in 17 patients with colon cancer. While a heterogeneous pattern was observed for the expression level of the PPAR-isoforms alpha,beta/delta and gamma, the coactivator PGC-1 was significantly decreased in 15 of 17 tumors. Taken together our data suggest that the transcriptional activity of PPARgamma may not only be decreased by mutation but also by downregulation of the coactivator PGC-1 of PPARgamma. Adult Aged Colonic Neoplasms/genetics/metabolism Down-Regulation Female Humans Male Middle Aged Mutation Protein Isoforms/metabolism Receptors, Cytoplasmic and Nuclear/genetics/metabolism Receptors, Retinoic Acid/metabolism Retinoid X Receptors Reverse Transcriptase Polymerase Chain Reaction Transcription Factors/genetics/metabolism Dewey 616 Dewey 617 56 Département de médecine 221 57 Département de chirurgie 222 false 79 Chirurgie viscérale 104 1329 Chirurgie viscérale (HUG) Cancer letters 203 1 8a66a95d-e22f-4d93-ab43-bfcebdd07271 Article (Published version) Restricted 1-s2.0-S0304383503005834-main.pdf 264898 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1)	Cancer letters			2004	744	0

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Feilchenfeldt, Jonas Walter