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Scientific article
English

Increased salt sensitivity of ambulatory blood pressure in women with a history of severe preeclampsia

Contributors

Martillotti Mbo, Gabriella; Ditisheim, Agnès; Burnier, Michel; Wagner, Ghislaine; Boulvain, Michel; Irion, Olivier; Pechere, Antoinette

Published in

Hypertension, vol. 62, no. 4, p. 802-808

Publication date

2013

Abstract

Cardiovascular diseases are the principal cause of death in women in developed countries and are importantly promoted by hypertension. The salt sensitivity of blood pressure (BP) is considered as an important cardiovascular risk factor at any BP level. Preeclampsia is a hypertensive disorder of pregnancy that arises as a risk factor for cardiovascular diseases. This study measured the salt sensitivity of BP in women with a severe preeclampsia compared with women with no pregnancy hypertensive complications. Forty premenopausal women were recruited 10 years after delivery in a case-control study. Salt sensitivity was defined as an increase of >4 mm Hg in 24-hour ambulatory BP on a high-sodium diet. The ambulatory BP response to salt was significantly increased in women with a history of preeclampsia compared with that of controls. The mean (95% confidence interval) daytime systolic/diastolic BP increased significantly from 115 (109-118)/79 (76-82) mm Hg on low-salt diet to 123 (116-130)/80 (76-84) on a high-salt diet in women with preeclampsia, but not in the control group (from 111 [104-119]/77 [72-82] to 111 [106-116]/75 [72-79], respectively, P<0.05). The sodium sensitivity index (SSI=Δmean arterial pressure/Δurinary Na excretion×1000) was 51.2 (19.1-66.2) in women with preeclampsia and 6.6 (5.8-18.1) mm Hg/mol per day in controls (P=0.015). The nocturnal dip was blunted on a high-salt diet in women with preeclampsia. Our study shows that women who have developed preeclampsia are salt sensitive before their menopause, a finding that may contribute to their increased cardiovascular risk. Women with a history of severe preeclampsia should be targeted at an early stage for preventive measures of cardiovascular diseases.

Keywords

  • Adult
  • Blood Pressure/physiology
  • Blood Pressure Monitoring, Ambulatory
  • Female
  • Humans
  • Hypertension/diagnosis/physiopathology
  • Middle Aged
  • Pre-Eclampsia/physiopathology
  • Pregnancy
  • Prospective Studies
  • Severity of Illness Index
  • Sodium, Dietary

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

MARTILLOTTI MBO, Gabriella et al. Increased salt sensitivity of ambulatory blood pressure in women with a history of severe preeclampsia. In: Hypertension, 2013, vol. 62, n° 4, p. 802–808. doi: 10.1161/HYPERTENSIONAHA.113.01916

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0194-911X
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Technical informations

Creation

15/10/2014 15:23:00

First validation

15/10/2014 15:23:00

Update

14/03/2023 21:51:36

Status update

14/03/2023 21:51:35

Last indexation

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